Tag: Antagonist

For research use only. We do not sell to patients. Alvimopan-d5 CAS No. : 1217616-62-0 Biological Activity：Alvimopan-d5 is the deuterium labeled Alvimopan. Alvimopan (ADL 8-2698) is a potent, selective, orally active and reversible μ-opioid receptor antagonist, with an IC50 of 1.7 nM. Alvimopan has selectivity for μ-opioid receptor (Ki=0.47 nM) over κ- and δ-opioid receptors […]

For research use only. We do not sell to patients. MRT-10 CAS No. : 330829-30-6 Biological Activity：MRT-10 is a seven-transmembrane receptor smoothened (Smo) antagonist with an IC50 of 0.65 μM in the micromolar range in various Hedgehog (Hh) assays. MRT-10 binds to the Smo receptor at the level of the Bodipycyclopamine binding site. MRT-10 can […]

For research use only. We do not sell to patients. GX-674 CAS No. : 1432913-36-4 Biological Activity：GX-674 is a potent, state-dependent, isoform-selective voltage-gated sodium channel 1.7 (Nav1.7) antagonist with an IC50 of 0.1 nM at -40 mV. Research Area：Neurological Disease|Cardiovascular Disease Targets：Sodium Channel Related Small Molecules:Lu AE98134;Zandatrigine;Veratridine;Brompheniramine-d6 maleate;Dibucaine;Sodium Channel inhibitor 2;3-Deoxyaconitine;20(S)-Ginsenoside Rg3;Tocainide hydrochloride;Licarbazepine-d4-1;Metaflumizone-d4;β-Pompilidotoxin;Nav1.1 activator 1;ICA-121431;Brompheniramine […]

For research use only. We do not sell to patients. Hemopressin(rat) TFA Biological Activity：Hemopressin(rat) TFA is a nonapeptide derived from the α1-chain of hemoglobin, is originally isolated from rat brain homogenates. Hemopressin(rat) TFA is orally active, selective and inverse agonist of CB1 cannabinoid receptors. Hemopressin(rat) TFA exerts antinociceptive action in inflammatory pain models[2]. Research Area：Neurological […]

For research use only. We do not sell to patients. Samelisant CAS No. : 1394808-20-8 Biological Activity：Samelisant (SUVN-G3031) is a potent and selective histamine H3 receptor (H3R) inverse agonist with good brain penetration and oral bioavailability. Samelisant has a similar binding affinity towards human (hH3R; Ki=8.7 nM) and rat (rH3R;Ki=9.8 nM) H3R indicating no inter-species […]

For research use only. We do not sell to patients. Nilvadipine CAS No. : 75530-68-6 Biological Activity：Nilvadipine is a potent calcium channel antagonist, and the IC50 value is around 0.1 nM. Research Area：Cardiovascular Disease Targets：Calcium Channel Related Screening Libraries:Covalent Screening Library Plus;Drug Repurposing Compound Library Plus;FDA-Approved Drug Library Plus;FDA-Approved Drug Library Mini;Bioactive Compound Library Plus;Membrane […]

For research use only. We do not sell to patients. THX-B CAS No. : 1372206-64-8 Biological Activity：THX-B is a potent and non-peptidic p75NTR (neurotrophin receptor p75) antagonist. THX-B can be used in the research of diabetic kidney disease, neurodegenerative and inflammatory disorders[2][3]. Research Area：Metabolic Disease|Neurological Disease Targets：Neurotensin Receptor Related Small Molecules:NTRC-824;JMV 449;ML314;SORT-PGRN interaction inhibitor 1;AF38469;Kinetensin;Contulakin […]

For research use only. We do not sell to patients. CXCR4 antagonist 2 CAS No. : 2243636-57-7 Biological Activity：CXCR4 antagonist 2 is a CXCR4 antagonist with an IC50 value of 47 nM. Research Area：Others Targets：CXCR Related Small Molecules:Nicotinamide N-oxide;FC131;AMG 487 (S-enantiomer);CXCR4 antagonist 6;CXCR2 antagonist 4;VUF11207 fumarate;KRH-3955 hydrochloride;IT1t dihydrochloride;NBI-74330;MSX-130;SCH 546738;Elubrixin;CXCR2 antagonist 2;CXCR2-IN-1;Mavorixafor;HF51116;Reparixin L-lysine salt;HF50731;AZD-5069;AZD8797;BAM-12P;CTCE-0214;Baohuoside I;Ladarixin sodium;CXCR2 […]

For research use only. We do not sell to patients. SB-705498 CAS No. : 501951-42-4 Biological Activity：SB-705498 is a potent, selective and orally bioavailable transient receptor potential vanilloid 1 (TRPV1) receptor antagonist with a pIC50 of 7.1. Research Area：Neurological Disease Targets：TRP Channel Related Screening Libraries:Covalent Screening Library Plus;Drug Repurposing Compound Library Plus;Clinical Compound Library Plus;Bioactive […]

For research use only. We do not sell to patients. PF-04634817 succinate CAS No. : 2140301-98-8 Biological Activity：PF-0463481 succinate is a potent and orally active dual CCR2/CCR5 antagonist with comparable human and rodent CCR2 potency (rat IC50=20.8 nM), and displays 10-20 fold less rodent CCR5 potency (rat IC50=470 nM). PF-0463481 succinate is safe and well-tolerated […]