Tag: Antagonist

For research use only. We do not sell to patients. Haloperidol CAS No. : 52-86-8 Biological Activity：Haloperidol is a potent dopamine D2 receptor antagonist, widely used as an antipsychotic. Research Area：Neurological Disease Targets：Dopamine Receptor Related Screening Libraries:Drug Repurposing Compound Library Plus;FDA-Approved Drug Library Plus;FDA-Approved Drug Library Mini;Bioactive Compound Library Plus;GPCR/G Protein Compound Library;Neuronal Signaling Compound […]

For research use only. We do not sell to patients. CaV1.3 antagonist-1 CAS No. : 1391385-57-1 Biological Activity：CaV1.3 antagonist-1 is a potent and highly selective CaV1.3 L-type calcium channel (LTCC) antagonist with an IC50 of 1.7 μM. CaV1.3 antagonist-1 inhibits CaV1.3 LTCC >600-fold more potently than CaV1.2 LTCC. CaV1.3 antagonist-1, a cyclopentyl derivative, has the […]

For research use only. We do not sell to patients. BQ-788 CAS No. : 173326-37-9 Biological Activity：BQ-788 is a potent, selective ETB receptor antagonist with IC50 of 1.2 nM for inhibition of ET-1 binding to human Girardi heart cells, poorly inhibiting the binding to ETA receptors in human neuroblastoma cell line SK-N-MC cells with IC50 […]

For research use only. We do not sell to patients. AGN 193109-d7 CAS No. : 1216429-25-2 Biological Activity：AGN 193109-d7 is the deuterium labeled AGN 193109. AGN 193109 is a retinoid analog, and acts as a specific and highly effective antagonist of retinoic acid receptors (RARs), with Kds of 2 nM, 2 nM, and 3 nM […]

For research use only. We do not sell to patients. FPTQ CAS No. : 864863-72-9 Biological Activity：FPTQ is potent mGluR1 antagonist with IC50 values of 6 nM and 1.4 nM for human and mouse mGluR1 respectively. FPTQ has anti-oxidant and anti-inflammatory effects in vitro and in vivo[2]. Research Area：Others Targets：mGluR Related Screening Libraries:Bioactive Compound Library […]

For research use only. We do not sell to patients. DY268 CAS No. : 1609564-75-1 Biological Activity：DY268 is a farnesoid X receptor (FXR) antagonist (IC50=7.5 nM in a time-resolved FRET assay). It inhibits FXR transactivation in a cell-based assay with an IC50 value of 468 nM. Research Area：Metabolic Disease Targets：FXR Related Screening Libraries:Bioactive Compound Library […]

For research use only. We do not sell to patients. Bromopride-d3 CAS No. : 1189498-49-4 Biological Activity：Bromopride-d3 is the deuterium labeled Bromopride. Bromopride is a dopamine antagonist with prokinetic properties, widely used as an antiemetic. Research Area：Neurological Disease Targets：Dopamine Receptor Related Small Molecules:Alizapride hydrochloride;Thioproperazine;Nuciferine;Glaucine;SB-277011 dihydrochloride;MIF-1 TFA;Sulpiride;(Rac)-Razpipadon;Clebopride malate;WAY-100635;Flupentixol-d4 dihydrochloride;Cariprazine-d6 hydrochloride;Itopride-d6 hydrochloride;ONC206;Brexpiprazole S-oxide;cis-(Z)-Flupentixol dihydrochloride;D4R antagonist-1;U91356 Trending products：Recombinant […]

For research use only. We do not sell to patients. Adenosine 2′,5′-diphosphate sodium CAS No. : 154146-84-6 Biological Activity：Adenosine 2′,5′-diphosphate sodium is a competitive P2Y1 antagonist. Adenosine 2′,5′-diphosphate sodium exhibits non-selective antagonism at recombinant and human platelet P2X1 receptors[2]. Research Area：Others Targets：P2Y Receptor|Endogenous Metabolite Related Small Molecules:D-α-Hydroxyglutaric acid disodium;Nicotinamide N-oxide;3-Hydroxyglutaric acid-d5;DPPC-d62;SDMA-d6;2-Mercaptobenzothiazole;N-Acetyl-L-glutamic acid-d5;(3R,5S)-3-Hydroxy Cotinine-d3;Biliverdin hydrochloride;D-Glucose-13C,d1-3;2,3-Diaminopropionic acid […]

For research use only. We do not sell to patients. STING agonist-3 trihydrochloride Biological Activity：STING agonist-3 trihydrochloride, extracted from patent WO2017175147A1 (example 10), is a selective and non-nucleotide small-molecule STING agonist with a pEC50 and pEC50 of 7.5 and 9.5, respectively. STING agonist-3 trihydrochloride has durable anti-tumor effect and tremendous potential to improve treatment of cancer. Research […]

For research use only. We do not sell to patients. (D-Trp12,Tyr34)-pTH (7-34) amide (bovine) CAS No. : 118102-98-0 Biological Activity：(D-Trp12,Tyr34)-pTH (7-34) amide (bovine) is a potent and competitive antagonist of parathyroid hormone (PTH), with a Ki of 69 nM in bovine renal cortical membrane. (D-Trp12,Tyr34)-pTH (7-34) amide (bovine) can be used for growth and development […]