Tag: Antagonist

For research use only. We do not sell to patients. NCGC00229600 CAS No. : 1338824-20-6 Biological Activity：NCGC00229600 is an allosteric inverse agonist of thyrotropin receptor (TSHR). NCGC00229600 inhibits both TSH and stimulating antibody activation of TSHRs endogenously expressed in Graves’ disease. Research Area：Endocrinology Targets：TSH Receptor Related Screening Libraries:Bioactive Compound Library Plus;GPCR/G Protein Compound Library;Endocrinology Compound […]

For research use only. We do not sell to patients. JNJ16259685 CAS No. : 409345-29-5 Biological Activity：JNJ16259685 is a selective antagonist of mGlu1 receptor, and inhibits the synaptic activation of mGlu1 in a concentration-dependent manner with IC50 of 19 nM. Research Area：Neurological Disease Targets：mGluR Related Screening Libraries:Bioactive Compound Library Plus;GPCR/G Protein Compound Library;Neuronal Signaling Compound […]

For research use only. We do not sell to patients. Metipranolol CAS No. : 22664-55-7 Biological Activity：Metipranolol is a nonselective and orally active β-adrenergic receptor antagonist. Metipranolol can be used for hypertension and glaucoma research[2]. Research Area：Cardiovascular Disease Targets：Adrenergic Receptor Related Screening Libraries:Drug Repurposing Compound Library Plus;FDA-Approved Drug Library Plus;FDA-Approved Drug Library Mini;Bioactive Compound Library […]

For research use only. We do not sell to patients. Volinanserin-d4 hydrochloride CAS No. : 1217617-73-6 Biological Activity：Volinanserin-d4 (MDL100907-d4) hydrochloride is the deuterium labeled Volinanserin hydrochlorid. Volinanserin is a potent and selective antagonist of 5-HT2 receptor, with a Ki of 0.36 nM, and shows 300-fold selectivity for 5-HT2 receptor over 5-HT1c, alpha-1 and DA D2 […]

For research use only. We do not sell to patients. SR2211 CAS No. : 1359164-11-6 Biological Activity：SR2211 is a potent, selective synthetic RORγ modulator and functions as an inverse agonist, with a Ki of 105 nM and an IC50 of ~320 nM. Research Area：Inflammation/Immunology Targets：ROR Related Screening Libraries:Bioactive Compound Library Plus;Immunology/Inflammation Compound Library;Metabolism/Protease Compound Library;Small […]

For research use only. We do not sell to patients. Lixivaptan CAS No. : 168079-32-1 Biological Activity：Lixivaptan (VPA-985, WAY-VPA 985) is an orally active and selective vasopressin receptor V2 antagonist, with IC50 values of 1.2 and 2.3 nM for human and rat V2, respectively. Research Area：Cardiovascular Disease|Endocrinology Targets：Vasopressin Receptor Related Screening Libraries:Drug Repurposing Compound Library […]

For research use only. We do not sell to patients. BD1063 dhydrochloride CAS No. : 206996-13-6 Biological Activity：BD1063 dhydrochloride is a potent and selective sigma 1 receptor antagonist. Research Area：Metabolic Disease Targets：Sigma Receptor Related Screening Libraries:Bioactive Compound Library Plus;Neuronal Signaling Compound Library; Related Small Molecules:Phenyltoloxamine;E1R;EST73502;(±)-Vesamicol hydrochloride;Sigma-LIGAND-1;BMY-14802 hydrochloride;SKF 83959 hydrobromide;Pentoxyverine;SR-31747 free base;Antidepressant agent 3;PD 144418;EST64454 hydrochloride;Glycerol […]

For research use only. We do not sell to patients. Ganirelix CAS No. : 124904-93-4 Biological Activity：Ganirelix is a competitive and selective gonadotropin releasing hormone (GnRH) antagonist. Ganirelix prevents endogenous GnRH from inducing luteinising hormone (LH) and follicle stimulating hormone relea. Research Area：Metabolic Disease Targets：GnRH Receptor Related Small Molecules:(R)-Elagolix;Linzagolix;Relugolix-d6;[D-Ala6]-LH-RH;Relugolix;Teverelix;Alarelin Acetate;[D-Leu6, Val7]-LH-RH (1-9) Ethyl Amide;Kisspeptin 13;opigolix;sGnRH-A;Lecirelin;GnRH-R […]

For research use only. We do not sell to patients. Rp-8-CPT-cAMPS sodium CAS No. : 221905-35-7 Biological Activity：Rp-8-CPT-cAMPS sodium, a cAMP analog, is a potent and competitive antagonist of cAMP-induced activation of cAMP-dependent PKA I and II. Rp-8-CPT-cAMPS sodium preferentially selects site A of RI compares to site A of RII and site B of […]

For research use only. We do not sell to patients. Verlukast-d6 CAS No. : 153698-86-3 Biological Activity：Verlukast-d6 is a deuterium labeled Verlukast. Verlukast is a potent, selective, and orally active antagonist of leukotriene receptor. Verlukast has the potential for the research of asthma. Research Area：Inflammation/Immunology Targets：Leukotriene Receptor Related Small Molecules:Pranlukast-d4;Ablukast;CP-96486;MK-886;BIIL-260 hydrochloride;Pranlukast;γ-Linolenic acid ethyl ester;REV 5901;U-75302;RS-601;Tipelukast;LM-1484;RG-12525;Quinotolast […]