Tag: Agonist|Inhibitor

For research use only. We do not sell to patients. Fluticasone (propionate) CAS No. : 80474-14-2 Biological Activity：Fluticasone propionate, a potent topical anti-inflammatory corticosteroid, is a selective glucocorticoid receptor agonist, with an absolute affinity (KD) of 0.5 nM. Fluticasone propionate shows little or no activity at other steroid receptors. Anti-viral activity[2]. Research Area：Infection|Endocrinology|Inflammation/Immunology Targets：Enterovirus|Glucocorticoid Receptor|Endogenous […]

For research use only. We do not sell to patients. [DPro10] Dynorphin A (1-11), porcine CAS No. : 94596-26-6 Biological Activity：[DPro10] Dynorphin A (1-11), porcine, a N-Alkylated derivative, is a potent κ-opioid receptor agonist with a Ki value of 0.13 nM. [DPro10] Dynorphin A (1-11), porcine has analgesic property[2]. Research Area：Neurological Disease Targets：Adenylate Cyclase|Opioid Receptor […]

For research use only. We do not sell to patients. N-Desmethylclozapine-d8 hydrochloride CAS No. : 2705402-91-9 Biological Activity：Desmethylclozapine-d8 (Norclozapine-d8) hydrochloride is the deuterium labeled N-Desmethylclozapine hydrochloride. N-Desmethylclozapine hydrochloride is a major active metabolite of the atypical antipsychotic drug Clozapine. N-Desmethylclozapine hydrochloride is a potent, allosteric and partial M1 receptors agonist (EC50=115 nM) and is able […]

For research use only. We do not sell to patients. Loxoribine CAS No. : 121288-39-9 Biological Activity：Loxoribine (7-Allyl-8-oxoguanosine) is a guanosine analog with anti-viral and anti-tumor activities. Loxoribine is an orally bioavailable and selective Toll-like receptor (TLR) 7 agonist[2][3]. Research Area：Cancer|Infection Targets：Influenza Virus|Toll-like Receptor (TLR) Related Screening Libraries:Bioactive Compound Library Plus;Anti-Infection Compound Library;Immunology/Inflammation Compound Library;Anti-Cancer […]

For research use only. We do not sell to patients. APD668 CAS No. : 832714-46-2 Biological Activity：APD668 is a potent, selective and orally active agonist of G-protein coupled receptor GPR119, with EC50s of 2.7 nM and 33 nM for hGPR119 and rGPR119, respectively. APD668 shows no significant inhibition of any of the five major CYP […]

For research use only. We do not sell to patients. Fenofibric acid-d6 CAS No. : 1092484-69-9 Biological Activity：Fenofibric acid-d6 (FNF acid-d6) is the deuterium labeled Fenofibric acid. Fenofibric acid, an active metabolite of fenofibrate, is a PPAR activitor, with EC50s of 22.4 µM, 1.47 µM, and 1.06 µM for PPARα, PPARγ and PPARδ, respectively; Fenofibric […]

For research use only. We do not sell to patients. Amitraz-d3 Biological Activity：Amitraz-d3 is the deuterium labeled Amitraz. Amitraz is a non-systemic acaricide and insecticide, with alpha-adrenergic agonist activity, interaction with octopamine receptors of the central nervous system and inhibition of monoamine oxidases and prostaglandin synthesis. Research Area：Infection|Endocrinology Targets：Parasite|Adrenergic Receptor|Monoamine Oxidase Related Small Molecules:(+)-Isopulegol;SR9186;Antileishmanial agent-2;Azlocillin […]

For research use only. We do not sell to patients. Naphazoline hydrochloride CAS No. : 550-99-2 Biological Activity：Naphazoline (Naphthazoline) hydrochloride is a potent α-adrenergic receptor agonist. Naphazoline hydrochloride reduces vascular hyperpermeability and promotes vasoconstriction. Naphazoline hydrochloride reduces the levels of inflammatory factors (TNF-α, IL-1β and IL-6), cytokines (IFN-γ and IL-4), IgE, GMCSF, and NGF。Naphazoline hydrochloride […]

For research use only. We do not sell to patients. DPP-4/GPR119 modulator 1 CAS No. : 2411099-68-6 Biological Activity：DPP-4/GPR119 modulator 1 (Compound 22) is an orally active dipeptidyl peptidase IV (DPP-IV) inhibitor and GPR119 agonist. DPP-4/GPR119 modulator 1 shows blood glucose-lowering effect and moderate inhibition on hERG channel with an IC50 of 4.9 µM. DPP-4/GPR119 […]

For research use only. We do not sell to patients. Agmatine sulfate CAS No. : 2482-00-0 Biological Activity：Agmatine sulfate exerts modulatory action at multiple molecular targets, such as neurotransmitter systems, ion channels and nitric oxide synthesis. It is an endogenous agonist at imidazoline receptor and a NO synthase inhibitor. Research Area：Neurological Disease|Cancer Targets：NO Synthase|Imidazoline Receptor|Endogenous […]