Tag: Agonist|Inhibitor

For research use only. We do not sell to patients. Methylprednisolone-d7 Biological Activity：Methylprednisolone-d7 is deuterium labeled Methylprednisolone. Methylprednisolone is a synthetic corticosteroid with anti-inflammatory and immunomodulating properties. Methylprednisolone improve severe or critical COVID-19 by activating ACE2 and reducing IL-6 levels[3]. Research Area：Cancer|Infection|Endocrinology|Inflammation/Immunology Targets：Autophagy|Glucocorticoid Receptor|SARS-CoV Related Small Molecules:Deflazacort-D5;SARS-CoV-2-IN-33;GRL-0496;Grazoprevir potassium salt;SARS-CoV-2-IN-19;Molnupiravir;SARS-CoV-2 Mpro-IN-3;MM3122;Ketotifen fumarate;SARS-CoV-2-IN-16;Thapsigargin;INSCoV-614(1B);PPARγ/GR modulator 1;Anti-SARS-CoV-2 Spike mAb […]

For research use only. We do not sell to patients. N-Desmethylclozapine CAS No. : 6104-71-8 Biological Activity：N-Desmethylclozapine is a major active metabolite of the atypical antipsychotic drug Clozapine. N-Desmethylclozapine is a potent, allosteric and partial M1 receptors agonist (EC50=115 nM) and is able to potentiate hippocampal N-methyl-d-aspartate (NMDA) receptor currents through M1 receptor activation. N-Desmethylclozapine […]

For research use only. We do not sell to patients. Dynorphin A (1-10) (TFA) Biological Activity：Dynorphin A (1-10) (TFA), an endogenous opioid neuropeptide, binds to extracellular loop 2 of the κ-opioid receptor. Dynorphin A (1-10) (TFA) also blocks NMDA-activated current with an IC50 of 42.0 μM. Research Area：Neurological Disease Targets：Opioid Receptor|iGluR Related Screening Libraries:Bioactive Compound […]

For research use only. We do not sell to patients. L-Glutamine-15N2 CAS No. : 204451-48-9 Biological Activity：L-Glutamine-15N2 (L-Glutamic acid 5-amide-15N2) is the 15N-labeled L-Glutamine. L-Glutamine (L-Glutamic acid 5-amide) is a non-essential amino acid present abundantly throughout the body and involved in many metabolic processes. L-Glutamine provides a source of carbons for oxidation in some cells[2]. […]

For research use only. We do not sell to patients. (E)-3,4,5-Trimethoxycinnamic acid CAS No. : 20329-98-0 Biological Activity：(E)-3,4,5-Trimethoxycinnamic acid (TMCA) is a cinnamic acid substituted by multi-methoxy groups. (E)-3,4,5-Trimethoxycinnamic acid is an orally active and potent GABAA/BZ receptor agonist. (E)-3,4,5-Trimethoxycinnamic exhibits favourable binding affinity to 5-HT2C and 5-HT1A receptor, with IC50 values of 2.5 and […]

For research use only. We do not sell to patients. 3M-011 CAS No. : 642473-62-9 Biological Activity：3M-011 is a potent dual toll-like receptor TLR7/8 agonist and a cytokine inducer. 3M-011 significantly inhibits H3N2 influenza viral replication in the nasal cavity. 3M-011 is also a potent adjuvant to radiotherapy that induces local and profound systemic immune […]

For research use only. We do not sell to patients. Fenofibric acid CAS No. : 42017-89-0 Biological Activity：Fenofibric acid, an active metabolite of fenofibrate, is a PPAR activitor, with EC50s of 22.4 µM, 1.47 µM, and 1.06 µM for PPARα, PPARγ and PPARδ, respectively; Fenofibric acid also inhibits COX-2 enzyme activity, with an IC50 of […]

For research use only. We do not sell to patients. Leelamine-d4 hydrochloride Biological Activity：Leelamine-d4 hydrochloride is the deuterium labeled Leelamine hydrochloride. Leelamine hydrochloride is a tricyclic diterpene molecule that is extracted from the bark of pine trees. Leelamine hydrochloride is a cannabinoid receptor type 1 (CB1) agonist and a inhibitor of SREBP1-regulated fatty acid/lipid synthesis […]

For research use only. We do not sell to patients. Roxindole CAS No. : 112192-04-8 Biological Activity：Roxindole (EMD 49980), an indot-alkyl-pipenidine, is a potent agonist at dopamine autoreceptors, with an affinity for the D2-like subtype in the low nanomolar range. Roxindole can be used for the research of positive and negative schizophrenic symptoms. Roxindole is […]

For research use only. We do not sell to patients. Probenecid-d14 CAS No. : 1189657-87-1 Biological Activity：Probenecid-d14 is the deuterium labeled Probenecid. Probenecid is a potent and selective agonist of transient receptor potential vanilloid 2 (TRPV2) channels. Probenecid also inhibits pannexin 1 channels[2]. Research Area：Metabolic Disease Targets：TRP Channel|HIV|Bacterial Related Small Molecules:V116517;Sandramycin;LLO (91-99);Gepotidacin;Oritavancin;GSK2332255B;Azlocillin sodium salt;Herbimycin A;Pregnenolone […]