Tag: Agonist|Antagonist

For research use only. We do not sell to patients. WAY-100635 CAS No. : 162760-96-5 Biological Activity：WAY-100635 is a potent and selective 5-HT1A Receptor antagonist with a pIC50 of 8.87, an apparent pA2 of 9.71. WAY-100635 is a potent and selective 5-hydroxytryptamine 1A (5-HT1A) receptor antagonist with an IC50 value of 0.91 nM and Ki […]

For research use only. We do not sell to patients. EST73502 CAS No. : 1838622-25-5 Biological Activity：EST73502 is a selective, orally active and blood-brain barrier (BBB) penetrant dual μ-opioid receptor (MOR) agonist and σ1 receptor (σ1R) antagonist, with Kis of 64 nM and 118 nM for MOR and σ1R, respectively. EST73502 has antinociceptive activity. Research […]

For research use only. We do not sell to patients. BMY-14802 hydrochloride CAS No. : 105565-55-7 Biological Activity：BMY-14802 hydrochloride (BMY-14802-1) is a selective and orally active sigma receptor antagonist with an IC50 of 112 nM. BMY-14802 hydrochloride is also a 5-HT1A and adrenergic α1 receptors agonist. BMY-14802 hydrochloride has antipsychotic effects[2][3]. Research Area：Neurological Disease Targets：Adrenergic […]

For research use only. We do not sell to patients. (Rac)-Rotigotine-d7 hydrochloride Biological Activity：(Rac)-Rotigotine-d7 (hydrochloride) is deuterium labeled (Rac)-Rotigotine (hydrochloride). (Rac)-Rotigotine hydrochloride is a racemate of Rotigotine. Rotigotine is a full agonist of dopamine receptor, a partial agonist of the 5-HT1A receptor, and an antagonist of the α2B-adrenergic receptor, with Kis of 0.71 nM, 4-15 nM, and 83 nM for the dopamine […]

For research use only. We do not sell to patients. Tetrahydromagnolol CAS No. : 20601-85-8 Biological Activity：Tetrahydromagnolol (Magnolignan), a main metabolite of Magnolol, is a potent and selective cannabinoid CB2 receptor agonist with an EC50 of 170 nM and a Ki of 416 nM. Tetrahydromagnolol possesses 20-fold more selective for CB2 receptor than CB1 receptor. […]

For research use only. We do not sell to patients. Isoxsuprine-d6 hydrochloride Biological Activity：Isoxsuprine-d6 hydrochloride is the deuterium labeled Isoxsuprine hydrochloride. Isoxsuprine hydrochloride is a beta-adrenergic receptor agonist with Kis of 13.65 μΜ and 3.48 μΜ for myometrial and placcntal beta-adrenergic receptor, respectively. Isoxsuprine hydrochloride is also a NMDA receptor antagonist. Research Area：Neurological Disease|Endocrinology Targets：Adrenergic […]

For research use only. We do not sell to patients. Facinicline hydrochloride CAS No. : 677305-02-1 Biological Activity：Facinicline hydrochloride (RG3487 hydrochloride) is an orally active nicotinic α7 receptor partial agonist, with a Ki of 6 nM for α7 human nAChR. Facinicline hydrochloride (RG3487 hydrochloride) improves cognition and sensorimotor gating in rodents. Facinicline hydrochloride (RG3487 hydrochloride) […]

For research use only. We do not sell to patients. Talipexole dihydrochloride CAS No. : 36085-73-1 Biological Activity：Talipexole dihydrochloride (B-HT 920 dihydrochloride) is a dopamine D2 receptor agonist, α2-adrenoceptor agonist and 5-HT3 receptor antagonist, which displays antiParkinsonian activity. Research Area：Neurological Disease|Endocrinology Targets：Dopamine Receptor|Adrenergic Receptor|5-HT Receptor Related Screening Libraries:Drug Repurposing Compound Library Plus;FDA-Approved Drug Library Plus;FDA-Approved […]

For research use only. We do not sell to patients. 7-Desmethyl-3-hydroxyagomelatine-d3 Biological Activity：7-Desmethyl-3-hydroxyagomelatine-d3 (3-Hydroxy-7-desmethyl agomelatine-d3) is the deuterium labeled 7-Desmethyl-3-hydroxyagomelatine. 7-Desmethyl-3-hydroxyagomelatine (3-Hydroxy-7-desmethyl agomelatine), a metabolite of Agomelatine, has less activity than Agomelatine. Agomelatine is a melatonergic (MT1 and MT2) agonist and serotonergic (5HT2C) antagonist[2]. Research Area：Neurological Disease Targets：5-HT Receptor|Melatonin Receptor Related Small Molecules:F 13714;Mosapride-d5;Nuciferine;Renzapride;Melatonin-d3;LY 344864 […]

For research use only. We do not sell to patients. Quetiapine hemifumarate CAS No. : 111974-72-2 Biological Activity：Quetiapine hemifumarate is a 5-HT receptors agonist with a pEC50 of 4.77 for human 5-HT1A receptor. Quetiapine hemifumarate is a dopamine receptor antagonist with a pIC50 of 6.33 for human D2 receptor. Quetiapine hemifumarate has moderate to high […]