Tag: Activator|Modulator

For research use only. We do not sell to patients. Kobusin CAS No. : 36150-23-9 Biological Activity：Kobusin is a bisepoxylignan isolated from the Pnonobio biondii Pamp. Kobusin is an activator of CFTR and CaCCgie chloride channels and a inhibitor of ANO1/CaCC (calcium-activated chloride channel) channel[2]. Research Area：Inflammation/Immunology|Neurological Disease Targets：Chloride Channel|CFTR Related Small Molecules:PG01;CFTR corrector 8;CP-628006;Atractyloside […]

For research use only. We do not sell to patients. Tamoxifen-​d5 CAS No. : 157698-32-3 Biological Activity：Tamoxifen-d5 (ICI 47699-d5) is a deuterium labeled Tamoxifen. Tamoxifen (ICI 47699) is an orally active, selective estrogen receptor modulator (SERM). Tamoxifen is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity[2]. Research Area：Cancer Targets：Autophagy|HSP|Estrogen Receptor/ERR|Apoptosis Related […]

For research use only. We do not sell to patients. Genistin CAS No. : 529-59-9 Biological Activity：Genistin (Genistine), an isoflavone belonging to the phytoestrogen family, is a potent anti-adipogenic and anti-lipogenic agent. Genistin attenuates cellular growth and promotes apoptotic cell death breast cancer cells through modulation of ERalpha signaling pathway[2][3]. Research Area：Cancer|Metabolic Disease Targets：Estrogen Receptor/ERR|Apoptosis […]

For research use only. We do not sell to patients. PBOX 6 CAS No. : 290814-68-5 Biological Activity：PBOX 6 is a pyrrolo-1,5-benzoxazepine (PBOX) compound, acts as a microtubule-depolymerizing agent and an apoptotic agent. Research Area：Cancer Targets：Microtubule/Tubulin|Apoptosis Related Screening Libraries:Bioactive Compound Library Plus;Apoptosis Compound Library;Cell Cycle/DNA Damage Compound Library;Anti-Cancer Compound Library;Anti-Aging Compound Library;Oxygen Sensing Compound Library;Cytoskeleton […]

For research use only. We do not sell to patients. Hyperforin dicyclohexylammonium salt CAS No. : 238074-03-8 Biological Activity：Hyperforin dicyclohexylammonium salt (Hyperforin DCHA) is a transient receptor canonical 6 (TRPC6) channels activator. Hyperforin dicyclohexylammonium salt modulates Ca2+ levels by activating Ca2+-conducting non-selective canonical TRPC6 channels. Hyperforin dicyclohexylammonium salt shows antidepressant effect[2]. Research Area：Neurological Disease Targets：Calcium […]

For research use only. We do not sell to patients. Droloxifene CAS No. : 82413-20-5 Biological Activity：Droloxifene, a Tamoxifen derivative, is an orally active and selective estrogen receptor modulator. Droloxifene shows antiestrogenic and anti-implantation effects. Droloxifene induces p53 expression and apoptosis in MCF-7 cells. Droloxifene prevents bone loss in ovariectomized rats [2][3]. Research Area：Cancer Targets：Estrogen […]

For research use only. We do not sell to patients. Tamoxifen Citrate CAS No. : 54965-24-1 Biological Activity：Tamoxifen Citrate (ICI 46474) is an orally active, selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells[2][3].Tamoxifen Citrate is a […]

For research use only. We do not sell to patients. Fingolimod hydrochloride CAS No. : 162359-56-0 Biological Activity：Fingolimod hydrochloride (FTY720), an analog of sphingosine, is a potent sphingosine 1-phosphate (S1P) receptors modulator. Fingolimod hydrochloride is phosphorylated by sphingosine kinases, particularly by SK2, and then binds S1PR1, 3, 4, and 5. Fingolimod hydrochloride induces the internalization […]