Tag: Activator|Inhibitor

For research use only. We do not sell to patients. A-1210477 CAS No. : 1668553-26-1 Biological Activity：A-1210477 is a potent and selective inhibitor of MCL-1 with a Ki of 0.45 nM. A-1210477 specifically binds MCL-1 and promotes apoptosis of cancer cells in an MCL-1-dependent manner[2]. Research Area：Cancer Targets：Bcl-2 Family|Apoptosis Related Screening Libraries:Bioactive Compound Library Plus;Apoptosis […]

For research use only. We do not sell to patients. Phenformin hydrochloride CAS No. : 834-28-6 Biological Activity：Phenformin hydrochloride is an anti-diabetic drug from the biguanide class, can activate AMPK activity. Research Area：Cancer Targets：Autophagy|AMPK Related Screening Libraries:Drug Repurposing Compound Library Plus;FDA-Approved Drug Library Plus;FDA-Approved Drug Library Mini;Bioactive Compound Library Plus;Epigenetics Compound Library;Kinase Inhibitor Library;PI3K/Akt/mTOR Compound […]

For research use only. We do not sell to patients. Tozasertib CAS No. : 639089-54-6 Biological Activity：Tozasertib (VX 680; MK-0457) is an inhibitor of Aurora A/B/C kinases with Kis of 0.6, 18, 4.6 nM, respectively. Research Area：Cancer Targets：Autophagy|Aurora Kinase Related Screening Libraries:Drug Repurposing Compound Library Plus;Clinical Compound Library Plus;Bioactive Compound Library Plus;Cell Cycle/DNA Damage Compound […]

For research use only. We do not sell to patients. EPZ004777 hydrochloride CAS No. : 1380316-03-9 Biological Activity：EPZ004777 hydrochloride is a potent, selective DOT1L inhibitor with an IC50 of 0.4 nM. Research Area：Cancer Targets：Histone Methyltransferase|Apoptosis Related Screening Libraries:Covalent Screening Library Plus;Bioactive Compound Library Plus;Apoptosis Compound Library;Epigenetics Compound Library;Histone Modification Research Compound Library;Anti-Cancer Compound Library;Covalent Screening […]

For research use only. We do not sell to patients. Tadalafil CAS No. : 171596-29-5 Biological Activity：Tadalafil (IC-351) is a PDE5 inhibitor with an IC50 value of 1.8 nM. Research Area：Cardiovascular Disease Targets：Phosphodiesterase (PDE)|Apoptosis Related Screening Libraries:Drug Repurposing Compound Library Plus;FDA-Approved Drug Library Plus;FDA-Approved Drug Library Mini;Bioactive Compound Library Plus;Apoptosis Compound Library;Metabolism/Protease Compound Library;FDA-Approved Drug […]

For research use only. We do not sell to patients. Vatalanib dihydrochloride CAS No. : 212141-51-0 Biological Activity：Vatalanib dihydrochloride (PTK787 dihydrochloride) is an inhibitor of VEGFR2/KDR with IC50 of 37 nM. Research Area：Cancer Targets：VEGFR|Apoptosis Related Screening Libraries:Drug Repurposing Compound Library Plus;Clinical Compound Library Plus;Bioactive Compound Library Plus;Apoptosis Compound Library;Kinase Inhibitor Library;Protein Tyrosine Kinase Compound Library;Anti-Cancer […]

For research use only. We do not sell to patients. (3R,5S)-Fluvastatin CAS No. : 155229-75-7 Biological Activity：(3R,5S)-Fluvastatin is the 3R,5S-isomer Fluvastatin. Fluvastatin (XU 62-320 free acid) is a first fully synthetic, competitive HMG-CoA reductase inhibitor with an IC50 of 8 nM. Fluvastatin protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway[2][3]. Research […]

For research use only. We do not sell to patients. ZINC69391 CAS No. : 303094-67-9 Biological Activity：ZINC69391, a specific Rac1 inhibitor, interferes with Rac1-GEF interaction by masking Trp56 residue on Rac1 surface. ZINC69391 interferes with the interaction of Rac1 with Dock180 and reduces Rac1-GTP levels. ZINC69391 induces apoptosis, and shows antiproliferative and antimetastatic effects[2][3]. Research […]

For research use only. We do not sell to patients. RAD51 Inhibitor B02 CAS No. : 1290541-46-6 Biological Activity：RAD51 Inhibitor B02 (B02) is an inhibitor of human RAD51 with an IC50 of 27.4 μM. Research Area：Cancer Targets：RAD51|Apoptosis Related Screening Libraries:Bioactive Compound Library Plus;Apoptosis Compound Library;Cell Cycle/DNA Damage Compound Library;Anti-Cancer Compound Library;Anti-Aging Compound Library;Anti-Breast Cancer Compound […]

For research use only. We do not sell to patients. Pioglitazone CAS No. : 111025-46-8 Biological Activity：Pioglitazone (U 72107) is an orally active and selective PPARγ (peroxisome proliferator-activated receptor) agonist with high affinity binding to the PPARγ ligand-binding domain with EC50 of 0.93 and 0.99 μM for human and mouse PPARγ, respectively. Pioglitazone can be […]