Tag: Activator|Inhibitor

For research use only. We do not sell to patients. HLY78 CAS No. : 854847-61-3 Biological Activity：HLY78, a Lycorine (HY-N0288) derivative, is a potent activator of the Wnt/β-catenin signaling pathway. HLY78 targets the DIX domain of Axin and promotes the Axin-LRP6 (lipoprotein receptor-related protein 6) association, thus promoting LRP6 phosphorylation and Wnt signal transduction. HLY78 […]

For research use only. We do not sell to patients. Ganetespib CAS No. : 888216-25-9 Biological Activity：Ganetespib (STA-9090) is a heat shock protein 90 (HSP90) inhibitor which exhibits potent cytotoxicity in a wide variety of hematological and solid tumor cell lines. Ganetespib has antiangiogenic effects in colorectal cancer mediated through inhibition of HIF-1α and STAT3[2][3][4][5][6]. […]

For research use only. We do not sell to patients. PROTAC eEF2K degrader-1 CAS No. : 2458170-54-0 Biological Activity：PROTAC eEF2K degrader-1 (Compound 11l) is an eEF2K-Targeting PROTAC small molecule that induces apoptosis in MDA-MB-231 cells. PROTAC eEF2K degrader-1 mediates eEF2K degradation. Research Area：Cancer Targets：CaMK|PROTACs|Apoptosis Related Small Molecules:Physalin A;Bomedemstat ditosylate;PROTAC Sirt2 Degrader-1;DB0614;Enpp/Carbonic anhydrase-IN-1;GK563;Calpeptin;Lobetyolin;BJE6-106;Dinaciclib;Ecteinascidin 770;MDM2-p53-IN-15;AT9283;Staurosporine;SNS-032;C188-9;ZLDI-8;Topoisomerase I/II inhibitor […]

For research use only. We do not sell to patients. Vibsanin A CAS No. : 72506-14-0 Biological Activity：Vibsanin A, a protein kinase C (PKC) activator, exhibits anti-proliferative activity against human cancer cell lines. Vibsanin A is also a HSP90 inhibitor. Research Area：Cancer Targets：HSP|PKC Related Small Molecules:[Ala107]MBP(104-118) TFA;BJE6-106;Myelin Basic Protein;Staurosporine;PKC-iota inhibitor 1;6BrCaQ;Hypericin;116-9e;Malantide;PKCiota-IN-2 formic;Paeoniflorin;HDAC/HSP90-IN-4;Debio 0932;MKT-077;Ethoxyquin;Cemdomespib;PF-4950834;C8 Dihydroceramide;SC-9;DL-erythro-Dihydrosphingosine;Safingol;Apatorsen;HS-131;CH5138303 Trending […]

For research use only. We do not sell to patients. Evocarpine CAS No. : 15266-38-3 Biological Activity：Evocarpine, a quinolone alkaloid that could be isolated from Evodiae fructus, inhibitss Ca2+ influx through voltage-dependent calcium channels. Antimycobacterial activity[2]. Research Area：Cancer|Infection|Inflammation/Immunology Targets：Bacterial|Apoptosis Related Screening Libraries:Natural Product Library Plus;Bioactive Compound Library Plus;Anti-Infection Compound Library;Apoptosis Compound Library;Immunology/Inflammation Compound Library;Natural Product […]

For research use only. We do not sell to patients. GSK2256098 CAS No. : 1224887-10-8 Biological Activity：GSK2256098 is a selective FAK kinase inhibitor, which inhibits growth and survival of pancreatic ductal adenocarcinoma cells. Research Area：Cancer Targets：FAK|Apoptosis Related Screening Libraries:Drug Repurposing Compound Library Plus;Clinical Compound Library Plus;Bioactive Compound Library Plus;Apoptosis Compound Library;Kinase Inhibitor Library;Protein Tyrosine Kinase […]

For research use only. We do not sell to patients. MHY1485 CAS No. : 326914-06-1 Biological Activity：MHY1485 is a potent cell-permeable mTOR activator that targets the ATP domain of mTOR. MHY1485 inhibits autophagy by suppression of fusion between autophagosomes and lysosomes. Research Area：Cancer Targets：Autophagy|mTOR Related Screening Libraries:Bioactive Compound Library Plus;Kinase Inhibitor Library;PI3K/Akt/mTOR Compound Library;Stem Cell […]

For research use only. We do not sell to patients. TC ASK 10 CAS No. : 1005775-56-3 Biological Activity：TC ASK 10 (Compound 10) is a potent, selective and orally active apoptosis signal-regulating kinase 1 (ASK1) inhibitor with an IC50 of 14 nM. The inhibitory activities of TC ASK 10 towards other representative panel of kinases […]

For research use only. We do not sell to patients. SZL P1-41 CAS No. : 222716-34-9 Biological Activity：SZL P1-41 is a specific Skp2 inhibitor, binds to the F-box domain of Skp2 to prevent Skp1 association and Skp2 SCF complex formation. SZL P1-41, like Skp2 deficiency, augments p27-mediated apoptosis/senescence, while it impairs Akt-driven glycolysis. Anti-tumor activities[2]. […]

For research use only. We do not sell to patients. 4′-Methoxyresveratrol CAS No. : 33626-08-3 Biological Activity：4′-Methoxyresveratrol (4′-O-Methylresveratrol) is a polyphenol derived from Dipterocarpaceae, with antiandrogenic, antifungal and anti-inflammatory activities. 4′-Methoxyresveratrol alleviates AGE-induced inflammation through suppressing RAGE-mediated MAPK/NF-κB signaling pathway and NLRP3 inflammasome activation. Research Area：Inflammation/Immunology Targets：NF-κB|NOD-like Receptor (NLR) Related Screening Libraries:Natural Product Library Plus;Bioactive […]