Tag: Activator|Inhibitor

For research use only. We do not sell to patients. TCS-PIM-1-4a CAS No. : 327033-36-3 Biological Activity：TCS-PIM-1-4a (SMI-4a) is a pan-Pim kinases inhibitor that blocks mTORC1 activity via activation of AMPK. TCS-PIM-1-4a kills a wide range of both myeloid and lymphoid cell lines (IC50 values ranging from 0.8 μM to 40 μM)[2]. Research Area：Cancer Targets：Pim|Apoptosis […]

For research use only. We do not sell to patients. (1S,2S)-Bortezomib CAS No. : 1132709-14-8 Biological Activity：(1S,2S)-Bortezomib is an enantiomer of Bortezomib. Bortezomib is a cell-permeable, reversible, and selective proteasome inhibitor, and potently inhibits 20S proteasome (Ki of 0.6 nM) by targeting a threonine residue. Bortezomib disrupts the cell cycle, induces apoptosis, and inhibits NF-κB. […]

For research use only. We do not sell to patients. Pravastatin CAS No. : 81093-37-0 Biological Activity：Pravastatin (CS-514) is a competitive HMG-CoA reductase inhibitor against sterol synthesis with IC50 of 5.6 μM. Research Area：Cardiovascular Disease|Cancer Targets：Autophagy|HMG-CoA Reductase (HMGCR) Related Small Molecules:β-Amyrin acetate;SR12813;Cerivastatin;Meglutol;Hesperetin 7-O-glucoside;Monacolin J;QH536;β-Amyrin palmitate;HMG499;Clinofibrate;Mevastatin;S-2E Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  […]

For research use only. We do not sell to patients. D-erythro-Sphingosine CAS No. : 123-78-4 Biological Activity：D-erythro-Sphingosine (Erythrosphingosine) is a very potent activator of p32-kinase with an EC50 of 8 μM, and inhibits protein kinase C (PKC). D-erythro-Sphingosine (Erythrosphingosine) is also a PP2A activator[2][3][4]. Research Area：Cancer Targets：PKC|Phosphatase|Endogenous Metabolite Related Screening Libraries:Natural Product Library Plus;Bioactive Compound […]

For research use only. We do not sell to patients. VR23 CAS No. : 1624602-30-7 Biological Activity：VR23 is a small molecule that potently inhibits the activities of trypsin-like proteasomes (IC50=1 nM), chymotrypsin-like proteasomes (IC50=50-100 nM), and caspase-like proteasomes (IC50=3 μM). Research Area：Metabolic Disease|Cancer Targets：Proteasome|Apoptosis Related Screening Libraries:Bioactive Compound Library Plus;Apoptosis Compound Library;Metabolism/Protease Compound Library;Anti-Cancer Compound […]

For research use only. We do not sell to patients. NQDI-1 CAS No. : 175026-96-7 Biological Activity：NQDI-1 inhibits apoptosis signal-regulating kinase 1 (ASK1) with a Ki of 500 nM and an IC50 of 3 μM. Research Area：Cancer Targets：MAP3K|Apoptosis Related Screening Libraries:Bioactive Compound Library Plus;Apoptosis Compound Library;Immunology/Inflammation Compound Library;Kinase Inhibitor Library;MAPK Compound Library;Anti-Cancer Compound Library;Oxygen Sensing […]

For research use only. We do not sell to patients. Jaspamycin CAS No. : 22242-96-2 Biological Activity：Jaspamycin (7-CN-7-C-Ino) is a potent activator of PKA, binding to the R site (PKAR), with an EC50 of 6.5 nM and Kd of 8 nM in Trypanosoma brucei. Jaspamycin (7-CN-7-C-Ino) does not bind with purified human PKARIα. Anti-parasite activity. […]

For research use only. We do not sell to patients. Bisindolylmaleimide VIII acetate CAS No. : 138516-31-1 Biological Activity：Bisindolylmaleimide VIII acetate (Ro 31-7549 acetate) is a potent and selective protein kinase C (PKC) inhibitor with an IC50 of 158 nM for rat brain PKC. Bisindolylmaleimide VIII acetate has IC50s of 53, 195, 163, 213, and […]

For research use only. We do not sell to patients. Mytoxin B CAS No. : 105049-15-8 Biological Activity：Mytoxin B is an ADC cytotoxin. Mytoxin B is a satratoxin-type trichothecene macrolide and is similar to the effect of LY294002 (HY-10108). Mytoxin B induces cell apoptosis via PI3K/Akt pathway. Research Area：Cancer Targets：ADC Cytotoxin|Apoptosis|PI3K Related Small Molecules:Physalin A;Bomedemstat […]

For research use only. We do not sell to patients. Trolox CAS No. : 53188-07-1 Biological Activity：Trolox is an analogue of vitamin E with a powerful antioxidant effect. Trolox is also a powerful inhibitor of membrane damage[2]. Research Area：Cancer Targets：Ferroptosis|Reactive Oxygen Species|Apoptosis Related Screening Libraries:Bioactive Compound Library Plus;Apoptosis Compound Library;Immunology/Inflammation Compound Library;Metabolism/Protease Compound Library;NF-κB Signaling […]