Tag: Activator|Inhibitor

For research use only. We do not sell to patients. GSK2656157 CAS No. : 1337532-29-2 Biological Activity：GSK2656157 is a selective and ATP-competitive inhibitor of protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK) with an IC50 of 0.9 nM. Research Area：Cancer Targets：PERK|Autophagy|Apoptosis Related Screening Libraries:Bioactive Compound Library Plus;Apoptosis Compound Library;Cell Cycle/DNA Damage Compound Library;Kinase Inhibitor Library;Anti-Cancer […]

For research use only. We do not sell to patients. 1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-(4-cyanophenoxy)phenyl)urea CAS No. : 1313019-65-6 Biological Activity：STAT3-IN-7 is a Sorafenib analogue and potently inhibits the phosphorylation of STAT3. STAT3-IN-7 induces cell apoptosis through SHP-1 dependent STAT3 inactivation. STAT3-IN-7 does not inhibit kinase activity and has anticancer effects. Research Area：Cancer Targets：STAT|Apoptosis Related Small Molecules:Physalin A;Bomedemstat ditosylate;Enpp/Carbonic […]

For research use only. We do not sell to patients. M3258 CAS No. : 2285330-15-4 Biological Activity：M3258 is an orally bioavailable, potent, reversible and highly selective immunoproteasome subunit LMP7 (β5i) inhibitor. M3258 exerts high biochemical (IC50=3.6 nM) and cellular (IC50=3.4 nM) potency against the LMP7 subunit. M3258 shows strong antitumor efficacy in multiple myeloma xenograft […]

For research use only. We do not sell to patients. UC-514321 CAS No. : 299420-83-0 Biological Activity：UC-514321, a structural analog of NSC370284 with higher activity, directly targets STAT3/5 and represses TET1 expression, but not TET2 or TET3. UC-514321 has the potential to treat acute myeloid leukemia (AML) both in vitro and in vivo, with low […]

For research use only. We do not sell to patients. Vandetanib trifluoroacetate CAS No. : 338992-53-3 Biological Activity：Vandetanib trifluoroacetate (D6474 trifluoroacetate) is a potent, orally active inhibitor of VEGFR2/KDR tyrosine kinase activity (IC50=40 nM). Vandetanib trifluoroacetate also has activity versus the tyrosine kinase activity of VEGFR3/FLT4 (IC50=110 nM) and EGFR/HER1 (IC50=500 nM). Research Area：Cancer Targets：Autophagy|VEGFR|Apoptosis […]

For research use only. We do not sell to patients. b-AP15 CAS No. : 1009817-63-3 Biological Activity：b-AP15 is a specific inhibitor of the deubiquitinating enzymes UCHL5 and Usp14. Research Area：Cancer Targets：Deubiquitinase|Apoptosis Related Screening Libraries:Bioactive Compound Library Plus;Peptidomimetic Library; Related Small Molecules:Physalin A;SJB3-019A;Bomedemstat ditosylate;SJB2-043;Enpp/Carbonic anhydrase-IN-1;GK563;Calpeptin;Lobetyolin;USP7-IN-1;BJE6-106;Dinaciclib;Ecteinascidin 770;MDM2-p53-IN-15;AT9283;Staurosporine;SNS-032;C188-9;ZLDI-8;Topoisomerase I/II inhibitor 3;Xevinapant;Mangiferin;Cambinol;Antioxidant agent-5;Apoptosis inducer 9;Bafetinib Trending products：Recombinant Proteins  |  […]

For research use only. We do not sell to patients. BAY 87-2243 CAS No. : 1227158-85-1 Biological Activity：BAY 87-2243 is a highly potent and selective hypoxia-inducible factor-1 (HIF-1) inhibitor. Research Area：Cancer Targets：Ferroptosis|HIF/HIF Prolyl-Hydroxylase Related Screening Libraries:Clinical Compound Library Plus;Bioactive Compound Library Plus;Apoptosis Compound Library;Epigenetics Compound Library;Immunology/Inflammation Compound Library;Metabolism/Protease Compound Library;Anti-Cancer Compound Library;Clinical Compound Library;Reprogramming Compound […]

For research use only. We do not sell to patients. Glabridin CAS No. : 59870-68-7 Biological Activity：Glabridin is a natural isoflavan from Glycyrrhiza uralensis, binds to and activates PPARγ, with an EC50 of 6115 nM. Glabridin exhibits antioxidant, anti-bacterial, anti-nephritic, anti-diabetic, anti-fungal, antitumor, anti-inflammatory, antiosteoporotic, cardiovascular protective, neuroprotective and radical scavenging activities[2]. Research Area：Cancer|Infection|Inflammation/Immunology Targets：Reactive […]

For research use only. We do not sell to patients. AZA1 CAS No. : 1071098-42-4 Biological Activity：AZA1 is a potent dual inhibitor of Rac1 and Cdc42. AZA1 induces prostate cancer cells apoptosis and inhibits prostate cancer cells proliferation, migration and invasion[2]. Research Area：Cancer Targets：Apoptosis|Ras Related Screening Libraries:Bioactive Compound Library Plus;Apoptosis Compound Library;GPCR/G Protein Compound Library;Kinase […]

For research use only. We do not sell to patients. CPT-Se3 Biological Activity：CPT-Se3, a selenoprodrug of Camptothecin (CPT), shows improved potency in killing cancer cells and inhibiting tumor growth. CPT–Se3 decreases the GSH/GSSG ratio and total thiols, elevates the ROS level in Hep G2 cells, and eventually induces apoptosis of cancer cells. CPT-Se3 shows cytotoxicity […]