Tag: Activator|Inhibitor

For research use only. We do not sell to patients. TPEN CAS No. : 16858-02-9 Biological Activity：TPEN (TPEDA) is a specific cell-permeable heavy metal chelator. TPEN has a higher affinity for Zn2+, but a lower affinity for Mg2+ and Ca2+. TPEN induces DNA damage and increases intracellular ROS production. TPEN also inhibits cell proliferation and […]

For research use only. We do not sell to patients. CP-724714 CAS No. : 383432-38-0 Biological Activity：CP-724714 is a potent, selective and orally active ErbB2 (HER2) tyrosine kinase inhibitor, with an IC50 of 10 nM. CP-724714 displays a marked selectivity against EGFR kinase (IC50=6400 nM). CP-724714 potently inhibits ErbB2 receptor autophosphorylation in intact cells. Antitumor […]

For research use only. We do not sell to patients. Tat-beclin 1 CAS No. : 1423821-88-8 Biological Activity：Tat-beclin 1, a peptide derived from a region of the autophagy protein (beclin 1), is a potent inducer of autophagy and interacts with negative regulator of autophagy, GAPR-1 (GLIPR2). Tat-beclin 1 decreases the accumulation of polyglutamine expansion protein […]

For research use only. We do not sell to patients. GSK2801 CAS No. : 1619994-68-1 Biological Activity：GSK2801 is a potent, selective, orally active and cell active acetyl-lysine competitive BAZ2A and BAZ2B bromodomains inhibitor with Kd values of 136 nM and 257 nM, respectively. GSK2801 shows >50-fold selectivity for BAZ2A/B over BRD4. Research Area：Cancer Targets：Epigenetic Reader […]

For research use only. We do not sell to patients. Fosbretabulin disodium CAS No. : 168555-66-6 Biological Activity：Fosbretabulin disodium (CA 4DP) is a tubulin destabilizing agent. Fosbretabulin disodium is the Combretastatin A4 prodrug that selectively targets endothelial cells, induces regression of nascent tumour neovessels, reduces tumour blood flow and causes central tumour necrosis[3]. Research Area：Cancer […]

For research use only. We do not sell to patients. GSK1324726A CAS No. : 1300031-52-0 Biological Activity：GSK1324726A is a novel, potent, and selective inhibitor of BET proteins with high affinity to BRD2 (IC50=41 nM), BRD3 (IC50=31 nM), and BRD4 (IC50=22 nM). Research Area：Cancer Targets：Epigenetic Reader Domain|Apoptosis Related Screening Libraries:Bioactive Compound Library Plus;Apoptosis Compound Library;Epigenetics Compound […]

For research use only. We do not sell to patients. NVP-TAE 684 CAS No. : 761439-42-3 Biological Activity：NVP-TAE 684 (TAE 684) is a highly potent and selective ALK inhibitor, which blocks the growth of ALCL-derived and ALK-dependent cell lines with IC50 values between 2 and 10 nM. Research Area：Cancer Targets：Anaplastic lymphoma kinase (ALK)|Apoptosis Related Screening […]

For research use only. We do not sell to patients. Kinsenoside CAS No. : 151870-74-5 Biological Activity：Kinsenoside is a main active component isolated from plants of the genus Anoectochilus, and exhibits many biological activities and pharmacological effects. Kinsenoside rescues the nucleus pulposus cells (NPCs) viability under oxidative stress and protects against apoptosis, senescence and mitochondrial […]

For research use only. We do not sell to patients. Suberoyl bis-hydroxamic acid CAS No. : 38937-66-5 Biological Activity：Suberoyl bis-hydroxamic acid (Suberohydroxamic acid; SBHA) is a competitive and cell-permeable HDAC1 and HDAC3 inhibitor with ID50 values of 0.25 μM and 0.30 μM, respectively.Suberoyl bis-hydroxamic acid renders MM cells susceptible to apoptosis and facilitates the mitochondrial […]

For research use only. We do not sell to patients. RO6889678 CAS No. : 1578153-27-1 Biological Activity：RO6889678 is a highly potent HBV capsid formation inhibitor with a complex absorption, distribution, metabolism, and excretion (ADME) profile. RO6889678 is a potent inducer of CYP3A4 and coregulated proteins in human hepatocytes. RO6889678 is metabolized by a combination of […]