Tag: Activator|Inhibitor

For research use only. We do not sell to patients. MAZ51 CAS No. : 163655-37-6 Biological Activity：MAZ51 is a selective inhibitor of VEGFR-3 (Flt-4) tyrosine kinase. MAZ51 inhibits VEGF-C-induced activation of VEGFR-3 without blocking VEGF-C-mediated stimulation of VEGFR2. MAZ51 had no effect on ligand-induced autophosphorylation of EGFR, IGF-1R and PDGFRβ. MAZ51 blocks proliferation and induces […]

For research use only. We do not sell to patients. Tacedinaline CAS No. : 112522-64-2 Biological Activity：Tacedinaline (N-acetyldinaline) is an inhibitor of the histone deacetylase (HDAC) with IC50s of 0.9, 0.9, 1.2 μM for recombinant HDAC 1, 2 and 3 respectively. Research Area：Cancer Targets：HDAC|Apoptosis Related Screening Libraries:Drug Repurposing Compound Library Plus;Clinical Compound Library Plus;Bioactive Compound […]

For research use only. We do not sell to patients. MI-136 CAS No. : 1628316-74-4 Biological Activity：MI-136 is an inhibitor of the menin-MLL protein-protein interaction (PPI), with an IC50 of 31 nM and a Kd of 23.6 nM. MI-136 shows to block AR signaling and has the potential for the study in castration-resistant tumors[2]. Research […]

For research use only. We do not sell to patients. UK-101 CAS No. : 1000313-40-5 Biological Activity：UK-101 is a potent and selective immunoproteasome β1i (LMP2) inhibitor with an IC50 value of 104 nM, displays 144- and 10-fold selectivity over β1c (IC50=15 μM) and β5 subunit (IC50=1 μM), respectivey. UK-101 induces cell apoptosis and can be […]

For research use only. We do not sell to patients. LCH-7749944 CAS No. : 796888-12-5 Biological Activity：LCH-7749944 (GNF-PF-2356) is a potent PAK4 inhibitor with an IC50 of 14.93 μM. LCH-7749944 effectively suppresses the proliferation of human gastric cancer cells through downregulation of PAK4/c-Src/EGFR/cyclin D1 pathway and induces apoptosis. Research Area：Cancer Targets：PAK|Apoptosis Related Screening Libraries:Covalent Screening […]

For research use only. We do not sell to patients. Eriodictyol CAS No. : 552-58-9 Biological Activity：Eriodictyol is a flavonoid isolated from the Chinese herb, with antioxidant and anti-inflammatory activity. Eriodictyol induces Nrf2 signaling pathway. Eriodictyol is also a potent influenza RNA-dependent RNA polymerase inhibitor with an IC50 of 18 nM. Research Area：Infection|Inflammation/Immunology Targets：Keap1-Nrf2|Influenza Virus|DNA/RNA […]

For research use only. We do not sell to patients. CKLF1-C27 CAS No. : 891861-48-6 Biological Activity：CKLF1-C27, a C-terminal peptide of CKLF1, binds to CCR4 receptor and activates ERK1/2 pathway. CKLF1-C27 can abrogate the effect of CKLF1 on cells by competing for CCR4 receptor. CKLF1-C27 shows great effect on promoting proliferation on HUVECs. CKLF1-C27 has the potential for psoriasis research. […]

For research use only. We do not sell to patients. CCT007093 CAS No. : 176957-55-4 Biological Activity：CCT007093 is an effective protein phosphatase 1D (PPM1D Wip1) inhibitor. Wip1 inhibition can activate the mTORC1 pathway and enhance hepatocyte proliferation after hepatectomy[2]. Research Area：Cancer Targets：Autophagy|Phosphatase|Apoptosis Related Screening Libraries:Bioactive Compound Library Plus;Apoptosis Compound Library;Metabolism/Protease Compound Library;Anti-Cancer Compound Library;Autophagy Compound […]

For research use only. We do not sell to patients. Targaprimir-96 CAS No. : 1655508-14-7 Biological Activity：Targaprimir-96 is a potent inhibitor of microRNA-96 (miR-96) processing. Targaprimir-96 selectively modulates miR-96 production in cancer cells and triggers apoptosis. Targaprimir-96 binds primary miR-96 (pri-miR-96) with low nanomolar affinity. Targaprimir-96 directly engages pri-miR-96 in breast cancer cells and is […]

For research use only. We do not sell to patients. Vismodegib CAS No. : 879085-55-9 Biological Activity：Vismodegib (GDC-0449) is an orally active hedgehog pathway inhibitor with an IC50 of 3 nM. Vismodegib also inhibits P-gp, ABCG2 with IC50 values of 3.0 μM and 1.4 μM, respectively[2]. Research Area：Cancer Targets：Autophagy|Hedgehog Related Screening Libraries:Drug Repurposing Compound Library […]