Tag: Activator|Inhibitor

For research use only. We do not sell to patients. Alexidine dihydrochloride CAS No. : 1715-30-6 Biological Activity：Alexidine dihydrochloride is an anticancer agent that targets a mitochondrial tyrosine phosphatase, PTPMT1, in mammalian cells and causes mitochondrial apoptosis. Alexidine dihydrochloride has antifungal and antibiofilm activity against a diverse range of fungal pathogens. Research Area：Infection Targets：Fungal|Apoptosis Related […]

For research use only. We do not sell to patients. Galegine hydrochloride CAS No. : 2368870-39-5 Biological Activity：Galegine hydrochloride, a guanidine derivative, contributes to weight loss in mice. Guanidine hydrochloride is the compound derived from G. officinalis, which gave rise to the biguanides, metformin and phenformin. Galegine hydrochloride activates AMPK in 3T3-L1 adipocytes and L6 […]

For research use only. We do not sell to patients. Voreloxin CAS No. : 175414-77-4 Biological Activity：Voreloxin (SNS-595; Vosaroxin; AG 7352) is a first-in-class topoisomerase II inhibitor that intercalates DNA and induces site-selective DNA DSB, G2 arrest, and apoptosis. Research Area：Cancer Targets：Topoisomerase|Apoptosis Related Small Molecules:Physalin A;Bomedemstat ditosylate;Gepotidacin;Enpp/Carbonic anhydrase-IN-1;GK563;Calpeptin;Lobetyolin;BJE6-106;Dinaciclib;Ecteinascidin 770;MDM2-p53-IN-15;AT9283;Staurosporine;SNS-032;C188-9;ZLDI-8;Topoisomerase I/II inhibitor 3;Xevinapant;Mangiferin;Cambinol;Antioxidant agent-5;Apoptosis inducer 9;Bafetinib;Cyclovirobuxine […]

For research use only. We do not sell to patients. Salermide CAS No. : 1105698-15-4 Biological Activity：Salermide is an inhibitor of Sirt1 and Sirt2; can cause strong cancer-specific apoptotic cell death. Research Area：Cancer Targets：Sirtuin|Apoptosis Related Screening Libraries:Bioactive Compound Library Plus;Apoptosis Compound Library;Cell Cycle/DNA Damage Compound Library;Epigenetics Compound Library;Histone Modification Research Compound Library;Anti-Cancer Compound Library;Anti-Aging Compound […]

For research use only. We do not sell to patients. Purmorphamine CAS No. : 483367-10-8 Biological Activity：Purmorphamine is a smoothened/Smo receptor agonist with an EC50 of 1 μM. Research Area：Neurological Disease|Cancer Targets：Autophagy|Smo Related Screening Libraries:Bioactive Compound Library Plus;Stem Cell Signaling Compound Library;Wnt/Hedgehog/Notch Compound Library;Anti-Cancer Compound Library;Autophagy Compound Library;Anti-Aging Compound Library;Reprogramming Compound Library;Anti-Pancreatic Cancer Compound Library; […]

For research use only. We do not sell to patients. 20(R)-Ginsenoside Rh2 CAS No. : 112246-15-8 Biological Activity：20(R)-Ginsenoside Rh2, a matrix metalloproteinase (MMP) inhibitor, acts as a cell antiproliferator. It has anticancer effects via blocking cell proliferation and causing G1 phase arrest. 20(R)-Ginsenoside Rh2 induces apoptosis, and has anti-inflammatory and antioxidative activity[2][3]. 20(R)-Ginsenoside Rh2 inhibits […]

For research use only. We do not sell to patients. OR-1855 CAS No. : 101328-85-2 Biological Activity：OR-1855, an active metabolite of Levosimendan, has effect on human myometrial contractility. Levosimendan is a calcium sensitiser used in the management of acutely decompensated congestive heart failure[2]. Research Area：Cardiovascular Disease Targets：Phosphodiesterase (PDE)|Autophagy|Potassium Channel Related Screening Libraries:Bioactive Compound Library Plus;Membrane […]

For research use only. We do not sell to patients. PI-273 CAS No. : 925069-34-7 Biological Activity：PI-273 is a first reversibly and specific phosphatidylinositol 4-kinase (PI4KIIα) inhibitor with an IC50 of 0.47 μM. PI-273 can inhibit breast cancer cell proliferation, block the cell cycle and induce cell apoptosis. Research Area：Cancer Targets：PI4K|Apoptosis Related Screening Libraries:Bioactive Compound […]

For research use only. We do not sell to patients. Cl-amidine CAS No. : 913723-61-2 Biological Activity：Cl-amidine is an orally active peptidylarginine deminase (PAD) inhibitor, with IC50 values of 0.8 μM, 6.2 μM and 5.9 μM for PAD1, PAD3, and PAD4, respectively. Cl-amidine induces apoptosis in cancer cells. Cl-amidine induces microRNA (miR)-16 (miRNA-16, microRNA-16) expression […]

For research use only. We do not sell to patients. 1G244 CAS No. : 847928-32-9 Biological Activity：1G244 is a potent DPP8/9 inhibitor with IC50s of 12 nM and 84 nM, respectively. 1G244 does not inhibit DPPIV and DPPII. 1G244 induces apoptosis in multiple myeloma cells and has anti-myeloma effects[2]. Research Area：Cancer Targets：Dipeptidyl Peptidase|Apoptosis Related Screening […]