Tag: Activator|Inhibitor

For research use only. We do not sell to patients. GSK5182 CAS No. : 877387-37-6 Biological Activity：GSK5182 is a highly selective and orally active inverse agonist of estrogen-related receptor γ (ERRγ) with an IC50 of 79 nM. GSK5182 does not interact with other nuclear receptors, including ERRα or ERα. GSK5182 also induces reactive oxyen species […]

For research use only. We do not sell to patients. Pentoxifylline CAS No. : 6493-05-6 Biological Activity：Pentoxifylline (BL-191), a haemorheological agent, is an orally active non-selective phosphodiesterase (PDE) inhibitor, with immune modulation, anti-inflammatory, hemorheological, anti-fibrinolytic and anti-proliferation effects. Pentoxifylline can be used for the research of peripheral vascular disease, cerebrovascular disease and a number of […]

For research use only. We do not sell to patients. Z-Ile-Leu-aldehyde CAS No. : 161710-10-7 Biological Activity：Z-Ile-Leu-aldehyde (Z-IL-CHO) is a potent and competitive peptide aldehyde inhibitor of γ-secretase and notch[2]. Research Area：Cancer Targets：Notch|γ-secretase|Apoptosis Related Screening Libraries:Covalent Screening Library Plus;Bioactive Compound Library Plus;Apoptosis Compound Library;Neuronal Signaling Compound Library;Stem Cell Signaling Compound Library;Wnt/Hedgehog/Notch Compound Library;Anti-Cancer Compound Library;Anti-Aging […]

For research use only. We do not sell to patients. UNC1999 CAS No. : 1431612-23-5 Biological Activity：UNC1999 is a SAM-competitive, potent and selective inhibitor of EZH2/1 with IC50s of

For research use only. We do not sell to patients. CDDO-dhTFEA CAS No. : 1191265-33-4 Biological Activity：CDDO-dhTFEA (RTA dh404) is a synthetic oleanane triterpenoid compound which potently activates Nrf2 and inhibits the pro-inflammatory transcription factor NF-κB. CDDO-dhTFEA restores hypertension (MAP), increases Nrf2 and expression of its target genes, attenuates activation of NF-κB and transforming growth […]

For research use only. We do not sell to patients. (3S,5R)-Rosuvastatin CAS No. : 1242184-42-4 Biological Activity：(3S,5R)-Rosuvastatin is the (3S,5R)-enantiomer of Rosuvastatin. Rosuvastatin is a competitive HMG-CoA reductase inhibitor with an IC50 of 11 nM. Rosuvastatin potently blocks human ether-a-go-go related gene (hERG) current with an IC50 of 195 nM[2]. Rosuvastatin reduces the expression of […]

For research use only. We do not sell to patients. Imeglimin hydrochloride CAS No. : 775351-61-6 Biological Activity：Imeglimin hydrochloride (EMD 387008) is an oral glucose-lowering agent. Imeglimin also reduces reactive oxygen species (ROS) production, increases mitochondrial DNA and improves mitochondrial function. Research Area：Metabolic Disease Targets：Reactive Oxygen Species|Mitochondrial Metabolism Related Screening Libraries:Drug Repurposing Compound Library Plus;FDA-Approved […]

For research use only. We do not sell to patients. Pravastatin-13C,d3 sodium Biological Activity：Pravastatin-13C,d3 (sodium) is the 13C- and deuterium labeled Pravastatin (sodium). Pravastatin sodium (CS-514 sodium) is an HMG-CoA reductase inhibitor against sterol synthesis with IC50 of 5.6 μM. Research Area：Cardiovascular Disease|Cancer Targets：Ferroptosis|Autophagy|HMG-CoA Reductase (HMGCR) Related Small Molecules:CIL56;DB0614;Ciclopirox-d11;Ciclopirox olamine;Curcumin;β-Amyrin acetate;SR12813;(-)-Epicatechin;Eugenol-d3;Artemisinin-d3;MMRi62;UAMC-3203;L-Glutamic acid-15N,d5;Chalcones A-N-5;Pifithrin-β hydrobromide;PD146176;Roxadustat;Matrine;Liproxstatin-1;Hemin Trending […]

For research use only. We do not sell to patients. Hydrochlorothiazide CAS No. : 58-93-5 Biological Activity：Hydrochlorothiazide (HCTZ), an orally active diuretic drug of the thiazide class, inhibits transforming TGF-β/Smad signaling pathway. Hydrochlorothiazide has direct vascular relaxant effects via opening of the calcium-activated potassium (KCA) channel. Hydrochlorothiazide improves cardiac function, reduces fibrosis and has antihypertensive […]

For research use only. We do not sell to patients. PTACH CAS No. : 848354-66-5 Biological Activity：PTACH (NCH-51) is a potent HDAC inhibitor with IC50s of 48 nM, 32 nM, and 41 nM for HDAC1, HDAC4, and HDAC6, respectively. PTACH exerts potent growth inhibition against various cancer cells (EC50s of 1.1-9.1 µM) [2]. Research Area：Cancer|Infection […]