Tag: Activator|Inhibitor

For research use only. We do not sell to patients. 10,11-Dehydrocurvularin CAS No. : 21178-57-4 Biological Activity：10,11-Dehydrocurvularin is a prevalent fungal phytotoxin and an antibiotic. 10,11-Dehydrocurvularin is a strong activator of the heat shock response. 10,11-Dehydrocurvularin inhibits TGF-β signalling pathway. Anti-tumorous activity[2]. Research Area：Cancer|Infection Targets：HSP|TGF-beta/Smad Related Small Molecules:TGFβ-IN-2;6BrCaQ;116-9e;Paeoniflorin;HDAC/HSP90-IN-4;Debio 0932;MKT-077;Ethoxyquin;Cemdomespib;Apatorsen;HS-131;CH5138303;Pimitespib;NCT-58;SRI-011381;Ponsegromab;MPC-0767;Retaspimycin;BOLD-100;Isoviolanthin;Onalespib;HSP90-IN-12;Palmitic acid-1-13C;Palmitic acid-d3;Feretoside;Palmitic acid-d9;Palmitic acid-13C2;Gamitrinib TPP;ALK5-IN-32 Trending […]

For research use only. We do not sell to patients. PP1 CAS No. : 172889-26-8 Biological Activity：PP1 is a potent, and Src family-selective tyrosine kinase inhibitor with IC50 of 5 and 6 nM for Lck and Fyn, respectively. Research Area：Cancer Targets：Src|Apoptosis Related Screening Libraries:Bioactive Compound Library Plus;Apoptosis Compound Library;Kinase Inhibitor Library;Protein Tyrosine Kinase Compound Library;Anti-Cancer […]

For research use only. We do not sell to patients. AG-825 CAS No. : 149092-50-2 Biological Activity：AG-825 (Tyrphostin AG-825) is a selective and ATP-competitive ErbB2 inhibitor which suppresses tyrosine phosphorylation, with an IC50 of 0.35 μM. AG-825 displays anti-cancer activity[2][3]. AG825 significantly accelerates apoptosis of human neutrophils[4]. AG-825 is a potential agent for overcoming Mn-induced […]

For research use only. We do not sell to patients. Etoposide phosphate disodium CAS No. : 122405-33-8 Biological Activity：Etoposide phosphate disodium (BMY-40481 disodium) is a potent anti-cancer chemotherapy agent and a selective topoisomerase II inhibitor to prevent re-ligation of DNA strands. Etoposide phosphate disodium is the phosphate ester prodrug of etoposide and is considered as active equivalent to […]

For research use only. We do not sell to patients. ML-210 CAS No. : 1360705-96-9 Biological Activity：ML-210 is a selective and covalent glutathione peroxidase 4 (GPX4) inhibitor with an EC50 of 30 nM. ML-210 binds the GPX4 selenocysteine residue. ML-210 has anti-cancer activity[2]. Research Area：Cancer Targets：Ferroptosis|Glutathione Peroxidase Related Screening Libraries:Covalent Screening Library Plus;Bioactive Compound Library […]

For research use only. We do not sell to patients. 8-Gingerol CAS No. : 23513-08-8 Biological Activity：8-Gingerol, found in the rhizomes of ginger (Z. officinale) with oral bioavailability, activates TRPV1, with an EC50 of 5.0 µM. 8-Gingerol inhibits COX-2, and inhibits the growth of H. pylori in vitro[2]. Research Area：Infection|Inflammation/Immunology|Cancer Targets：TRP Channel|Bacterial Related Screening Libraries:Natural […]

For research use only. We do not sell to patients. 2-Hexyl-4-pentynoic acid CAS No. : 96017-59-3 Biological Activity：2-Hexyl-4-pentynoic acid ((±)-2-Hexyl-4-pentynoic acid), valproic acid (VPA) derivative, exhibits potential roles of HDAC inhibition (IC50=13 µM) and HSP70 induction. Potent neuroprotective effects. 2-Hexyl-4-pentynoic acid causes histone hyperacetylation and protect against glutamate-induced excitotoxicity in cultured neurons. Research Area：Neurological Disease […]

For research use only. We do not sell to patients. NecroIr2 Biological Activity：NecroIr2 is an iridium(III) complex, serves as necroptosis inducers in Cisplatin (HY-17394)-resistant lung cancer cells (A549R). NecroIr2 selectively accumulates in mitochondria, leading to oxidative stress and loss of mitochondrial membrane potential (MMP). NecroIr2 activates receptor-interacting serine-threonine kinase 3 (RIPK3) and mixed lineage kinase […]

For research use only. We do not sell to patients. Sennidin B CAS No. : 517-44-2 Biological Activity：Sennidin B, a stereoisomer isolated from the leaves of Cassia angustifolia, has lower activity than Sennidin A. Sennidin A inhibits HCV NS3 helicase, with an IC50 of 0.8 μM. Sennidin A induces phosphorylation of Akt and glucose transporter […]

For research use only. We do not sell to patients. Sideroxylin CAS No. : 3122-87-0 Biological Activity：Sideroxylin is a C-methylated flavone isolated from Callistemon lanceolatus and exerts antimicrobial activity against Staphylococcus aureus. Sideroxylin inhibits ovarian cancer cell proliferation and induces apoptosis, causing DNA fragmentation, depolarization of the mitochondrial membrane, the generation of reactive oxygen species […]