Tag: Activator|Inhibitor

For research use only. We do not sell to patients. SKF1 CAS No. : 678997-25-6 Biological Activity：SKF1 is a FK506 suppressor, causes a mitochondrially induced death in low salt, concomitant with the release of reactive oxygen species (ROS). Research Area：Infection Targets：FKBP|Reactive Oxygen Species Related Small Molecules:D-α-Hydroxyglutaric acid disodium;Chitoheptaose heptahydrochloride;N-Acetyl-D-cysteine;Topoisomerase I/II inhibitor 3;CYPMPO;Antioxidant agent-5;dTAGV-1-NEG;ROS-ERS inducer 1;Glucosamine-13C […]

For research use only. We do not sell to patients. GGTI298 Trifluoroacetate CAS No. : 1217457-86-7 Biological Activity：GGTI298 Trifluoroacetate is a CAAZ peptidomimetic geranylgeranyltransferase I (GGTase I) inhibitor, which can inhibit Rap1A with IC50 of 3 μM; little effect on Ha-Ras with IC50 of >20 μM. Research Area：Cancer Targets：Apoptosis|Ras Related Screening Libraries:Covalent Screening Library Plus;Bioactive […]

For research use only. We do not sell to patients. (S)-Verapamil hydrochloride CAS No. : 36622-28-3 Biological Activity：(S)-Verapamil hydrochloride (S(-)-Verapamil hydrochloride) inhibits leukotriene C4 (LTC4) and calcein transport by MRP1. (S)-Verapamil hydrochloride leads to the death of potentially resistant tumor cells[2]. Research Area：Cancer Targets：Calcium Channel|Leukotriene Receptor|Apoptosis Related Screening Libraries:Drug Repurposing Compound Library Plus;FDA-Approved Drug Library […]

For research use only. We do not sell to patients. Ixazomib CAS No. : 1072833-77-2 Biological Activity：Ixazomib (MLN2238) is a selective, potent, and reversible proteasome inhibitor, which inhibits the chymotrypsin-like proteolytic (β5) site of the 20S proteasome with an IC50 of 3.4 nM (Ki of 0.93 nM). Research Area：Cancer Targets：Autophagy|Proteasome Related Screening Libraries:Covalent Screening Library […]

For research use only. We do not sell to patients. KCa1.1 channel activator-1 Biological Activity：KCa1.1 channel activator-1 (compound 1E), a Quercetin hybrid derivative, is a selective vascular KCa1.1 channel channel stimulator. KCa1.1 channel activator-1 also displays CaV1.2 channel blocking activity. KCa1.1 channel activator-1 exhibits weak myorelaxant activity. Research Area：Cardiovascular Disease Targets：Calcium Channel|Potassium Channel Related Small […]

For research use only. We do not sell to patients. AOH1160 CAS No. : 2089314-57-6 Biological Activity：AOH1160 is a potent, first-in-class, orally available small molecule proliferating cell nuclear antigen (PCNA) inhibitor, interferes with DNA replication, blocks homologous recombination-mediated DNA repair, causes cell-cycle arrest and induces apoptosis. AOH1160 selectively kills many types of cancer cells (mean […]

For research use only. We do not sell to patients. NVP-AEW541 CAS No. : 475489-16-8 Biological Activity：NVP-AEW541 (AEW541) is a potent inhibitor of IGF-1R with IC50 of 0.15 μM, also inhibits InsR, with IC50 of 0.14 μM. Research Area：Cancer|Endocrinology Targets：Insulin Receptor|Autophagy|IGF-1R Related Screening Libraries:Bioactive Compound Library Plus;Kinase Inhibitor Library;Protein Tyrosine Kinase Compound Library;Anti-Cancer Compound Library;Autophagy […]

For research use only. We do not sell to patients. Quisinostat CAS No. : 875320-29-9 Biological Activity：Quisinostat (JNJ-26481585) is a potent, second-generation and orally active pan-HDAC inhibitor (HDACi), with IC50 values ranging from 0.11 nM to 0.64 nM for HDAC1, HDAC2, HDAC4, HDAC10 and HDAC11. Quisinostat has a broad spectrum antitumoral activity. Quisinostat can induce […]

For research use only. We do not sell to patients. Batabulin CAS No. : 195533-53-0 Biological Activity：Batabulin (T138067) is an antitumor agent, which binds covalently and selectively to a subset of the β-tubulin isotypes, thereby disrupting microtubule polymerization. Batabulin affects cell morphology and leads to cell-cycle arrest ultimately induces apoptotic cell death. Research Area：Cancer Targets：Microtubule/Tubulin|Apoptosis […]

For research use only. We do not sell to patients. Amtolmetin guacil CAS No. : 87344-06-7 Biological Activity：Amtolmetin guacil is an effective nonsteroidal anti-Inflammatory agent with pain-relieving effects. Amtolmetin guacil inhibits prostaglandin synthesis and cyclooxygenase (COX). Amtolmetin guacil can stimulate capsaicin receptors present on the gastrointestinal wall and also releases gastroprotective nitric oxide (NO). Amtolmetin […]