Tag: Activator|Inhibitor

For research use only. We do not sell to patients. AZD-8055 CAS No. : 1009298-09-2 Biological Activity：AZD-8055 is a potent, selective, and orally bioavailable ATP-competitive mTOR kinase inhibitor with an IC50 of 0.8 nM. AZD-8055 inhibits both mTORC1 and mTORC2. Research Area：Cancer Targets：Autophagy|mTOR|Apoptosis Related Screening Libraries:Clinical Compound Library Plus;Bioactive Compound Library Plus;Apoptosis Compound Library;Kinase Inhibitor […]

For research use only. We do not sell to patients. MYCMI-6 CAS No. : 681282-09-7 Biological Activity：MYCMI-6 (NSC354961) is a potent and selective endogenous MYC:MAX protein interactions inhibitor. MYCMI-6 blocks MYC-driven transcription and binds selectively to the MYC bHLHZip domain with a Kd of 1.6 μM. MYCMI-6 inhibits tumor cell growth in a MYC-dependent manner (IC50

For research use only. We do not sell to patients. Marein CAS No. : 535-96-6 Biological Activity：Marein has the neuroprotective effect due to a reduction of damage to mitochondria function and activation of the AMPK signal pathway. Marein improves insulin resistance induced by high glucose in HepG2 cells through CaMKK/AMPK/GLUT1 to promote glucose uptake, through […]

For research use only. We do not sell to patients. YUM70 CAS No. : 423145-35-1 Biological Activity：YUM70 is a potent and selective inhibitor of glucose-regulated protein 78 (GRP78), with an IC50 of 1.5 μM for inhibiting GRP78 ATPase activity of the full-length protein. YUM70 induces endoplasmic reticulum (ER) stress-mediated apoptosis in pancreatic cancer. YUM70 also […]

For research use only. We do not sell to patients. R406 CAS No. : 841290-81-1 Biological Activity：R406 is an orally available and competitive Syk/FLT3 inhibitor for ATP binding with a Ki of 30 nM, potently inhibits Syk kinase activity in vitro with an IC50 of 41 nM, measured at an ATP concentration corresponding to its […]

For research use only. We do not sell to patients. MT 63-78 CAS No. : 1179347-65-9 Biological Activity：MT 63-78 is a specific and potent direct AMPK activator with an EC50 of 25 μM. MT 63–78 also induces cell mitotic arrest and apoptosis. MT 63-78 blocks prostate cancer growth by inhibiting the lipogenesis and mTORC1 pathways. […]

For research use only. We do not sell to patients. BRD6989 CAS No. : 642008-81-9 Biological Activity：BRD6989, an analog of the natural product cortistatin A (dCA), inhibits CDK8 and upregulates IL-10. BRD6989 selectively binds a complex of CDK8 with an IC50 of ~200 nM. BRD6989 inhibits the kinase activity of recombinant CDK8 or CDK19 complexes. […]

For research use only. We do not sell to patients. 1-Deoxynojirimycin hydrochloride CAS No. : 73285-50-4 Biological Activity：1-Deoxynojirimycin hydrochloride (Duvoglustat hydrochloride) is a potent and orally active α-glucosidase inhibitor. 1-Deoxynojirimycin hydrochloride suppresses postprandial blood glucose and is widely used for diabetes mellitus. 1-Deoxynojirimycin hydrochloride possesses antihyperglycemic, anti-obesity, and antiviral features[2]. Research Area：Infection|Metabolic Disease Targets：Glucosidase|Bacterial|Antibiotic|PI3K Related […]

For research use only. We do not sell to patients. CAY10505 CAS No. : 1218777-13-9 Biological Activity：CAY10505 is a potent and selective PI3Kγ inhibitor with an IC50 of 30 nM in neurons. Research Area：Cancer Targets：Apoptosis|PI3K Related Screening Libraries:Bioactive Compound Library Plus;Apoptosis Compound Library;Kinase Inhibitor Library;PI3K/Akt/mTOR Compound Library;Stem Cell Signaling Compound Library;Anti-Cancer Compound Library;Autophagy Compound Library;Anti-Aging […]

For research use only. We do not sell to patients. Pregnenolone monosulfate CAS No. : 1247-64-9 Biological Activity：Pregnenolone monosulfate (3β-Hydroxy-5-pregnen-20-one monosulfate) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone monosulfate acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated […]