Tag: Activator|Inhibitor

For research use only. We do not sell to patients. Brivanib CAS No. : 649735-46-6 Biological Activity：Brivanib (BMS-540215) is an ATP-competitive inhibitor against VEGFR2 with an IC50 of 25 nM, and has moderate potency against VEGFR-1 and FGFR-1, but >240-fold against PDGFR-β. Research Area：Cancer Targets：Autophagy|VEGFR Related Screening Libraries:Drug Repurposing Compound Library Plus;Clinical Compound Library Plus;Bioactive […]

For research use only. We do not sell to patients. NMDAR/TRPM4-IN-2 free base CAS No. : 1353979-43-7 Biological Activity：NMDAR/TRPM4-IN-2 free base (compound 8) is a potent NMDAR/TRPM4 interaction interface inhibitor. NMDAR/TRPM4-IN-2 free base shows neuroprotective activity. NMDAR/TRPM4-IN-2 free base prevents NMDA-induced cell death and mitochondrial dysfunction in hippocampal neurons, with an IC50 of 2.1 μM. […]

For research use only. We do not sell to patients. Saracatinib CAS No. : 379231-04-6 Biological Activity：Saracatinib (AZD0530) is a potent Src family inhibitor with IC50s of 2.7 to 11 nM for c-Src, Lck, c-YES, Lyn, Fyn, Fgr, and Blk. Saracatinib shows high selectivity over other tyrosine kinases. Research Area：Cancer Targets：Autophagy|Src Related Screening Libraries:Covalent Screening […]

For research use only. We do not sell to patients. Methyl cinnamate CAS No. : 103-26-4 Biological Activity：Methyl cinnamate (Methyl 3-phenylpropenoate), an active component of Zanthoxylum armatum, is a widely used natural flavor compound. Methyl cinnamate (Methyl 3-phenylpropenoate) possesses antimicrobial activity and is a tyrosinase inhibitor that can prevent food browning. Methyl cinnamate (Methyl 3-phenylpropenoate) […]

For research use only. We do not sell to patients. EF24 CAS No. : 342808-40-6 Biological Activity：EF24 is a curcumin analogue with greater anti-tumor efficacy and oral bioavailability via deactivation of the MAPK/ERK signaling pathway in oral squamous cell carcinoma (OSCC). EF24 treatment increases the levels of activated caspase 3 and 9, and decreases the […]

For research use only. We do not sell to patients. WYE-132 CAS No. : 1144068-46-1 Biological Activity：WYE-132 (WYE-125132) is a highly potent, ATP-competitive, and specific mTOR kinase inhibitor (IC50: 0.19±0.07 nM; >5,000-fold selective versus PI3Ks). WYE-132 (WYE-125132) inhibits mTORC1 and mTORC2. Research Area：Cancer Targets：mTOR|Apoptosis Related Screening Libraries:Covalent Screening Library Plus;Bioactive Compound Library Plus;Apoptosis Compound Library;Kinase […]

For research use only. We do not sell to patients. Sal003 CAS No. : 1164470-53-4 Biological Activity：Sal003 is a potent, specific and cell-permeable inhibitor of the eukaryotic translation initiation factor 2α (eIF2α) phosphatase. Sal003 is a derivative of salubrinal. Research Area：Cancer Targets：Phosphatase|Apoptosis Related Screening Libraries:Covalent Screening Library Plus;Bioactive Compound Library Plus;Apoptosis Compound Library;Metabolism/Protease Compound Library;Anti-Cancer […]

For research use only. We do not sell to patients. GDC-0349 CAS No. : 1207360-89-1 Biological Activity：GDC-0349 is a potent and selective ATP-competitive mTOR inhibitor with a Ki of 3.8 nM. GDC-0349 inhibits of both mTORC1 and mTORC2 complexes. Research Area：Cancer Targets：Autophagy|mTOR Related Screening Libraries:Covalent Screening Library Plus;Clinical Compound Library Plus;Bioactive Compound Library Plus;Kinase Inhibitor […]

For research use only. We do not sell to patients. Dehydrocrenatidine CAS No. : 65236-62-6 Biological Activity：Dehydrocrenatidine, a natural alkaloid, is a specific JAK inhibitor. Dehydrocrenatidine inhibits voltage-gated sodium channels and ameliorates mechanic allodia in a rat model of neuropathic pain[2]. Research Area：Cancer|Neurological Disease Targets：JAK|Apoptosis Related Small Molecules:Physalin A;Bomedemstat ditosylate;AZ-3;Enpp/Carbonic anhydrase-IN-1;GK563;Calpeptin;Lobetyolin;JAK3/BTK-IN-1;BJE6-106;Dinaciclib;Ecteinascidin 770;MDM2-p53-IN-15;AT9283;Staurosporine;SNS-032;C188-9;ZLDI-8;Topoisomerase I/II inhibitor 3;Xevinapant;Benzene […]

For research use only. We do not sell to patients. nor-NOHA acetate CAS No. : 1140844-63-8 Biological Activity：nor-NOHA acetate (Nω-Hydroxy-nor-L-arginine acetate) is a specific and reversible arginase inhibitor, induces apoptosis in ARG2-expressing cells under hypoxia but not normoxia. Anti-leukemic activity, effective in endothelial dysfunction, immunosuppression and metabolism. Research Area：Cancer|Metabolic Disease|Inflammation/Immunology Targets：Arginase|Apoptosis Related Small Molecules:Physalin A;Bomedemstat […]