Tag: Activator|Inhibitor

For research use only. We do not sell to patients. HE-S2 Biological Activity：HE-S2 is an antibody-drug conjugate triggering a potent antitumor immune response. HE-S2 acts by blocking the PD-1/PD-L1 interaction and activating the Toll-like receptor 7/8 (TLR7/8) signaling pathway. HE-S2 has remarkable antitumor activity. Research Area：Cancer|Infection Targets：PD-1/PD-L1|Drug-Linker Conjugates for ADC|Toll-like Receptor (TLR) Related Small Molecules:C29;TMX-201;L-Asparagine-N-Fmoc,N-beta-trityl-15N2;Val-Cit-PAB-MMAF […]

For research use only. We do not sell to patients. Alisol B 23-acetate CAS No. : 26575-95-1 Biological Activity：Alisol B 23-acetate (23-Acetylalismol B), a natural triterpenoid, produces protective effects against EE-induced cholestasis, due to FXR-mediated gene regulation. IC50 Value: Target: Anti-hepatotoxic natural product. In vitro: Alisol-B 23-acetate has an effect on FXR activation in a […]

For research use only. We do not sell to patients. Iberin CAS No. : 505-44-2 Biological Activity：Iberin (NSC 321801), a sulfoxide analogue of sulforaphane, is a naturally occurring member of isothiocyanate family. Iberin inhibits cell survival with an IC50 of 2.3 μM in HL60 cell. Iberin induces apoptosis. Research Area：Cancer Targets：Bacterial|Endogenous Metabolite|Apoptosis Related Small Molecules:D-α-Hydroxyglutaric […]

For research use only. We do not sell to patients. Alofanib CAS No. : 1612888-66-0 Biological Activity：Alofanib (RPT835) is a potent and selective allosteric inhibitor of fibroblast growth factor receptor 2 (FGFR2). Anticancer and antiangiogenic activity[2]. Research Area：Cancer|Cardiovascular Disease Targets：FGFR|Apoptosis Related Screening Libraries:Clinical Compound Library Plus;Bioactive Compound Library Plus;Apoptosis Compound Library;Kinase Inhibitor Library;Protein Tyrosine Kinase […]

For research use only. We do not sell to patients. STAT3-IN-3 CAS No. : 2361304-26-7 Biological Activity：STAT3-IN-3 is a potent and selective inhibitor of signal transducer and activator of transcription 3 (STAT3), with anti-proliferative activity. STAT3-IN-3 induces apoptosis in breast cancer cells. STAT3-IN-3 acts as a promising mitochondria-targeting STAT3 inhibitor for cancer research. Research Area：Cancer […]

For research use only. We do not sell to patients. BI-D1870 CAS No. : 501437-28-1 Biological Activity：BI-D1870 is an ATP-competitive, cell permeable and brain penetrated inhibitor of RSK isoforms, with IC50s of 31 nM/24 nM/18 nM/15 nM for RSK1/RSK2/RSK3/RSK4, respectively[2][3][4][5]. Research Area：Cancer Targets：Autophagy|Ribosomal S6 Kinase (RSK) Related Screening Libraries:Bioactive Compound Library Plus;Immunology/Inflammation Compound Library;Kinase Inhibitor […]

For research use only. We do not sell to patients. Dehydrocurdione CAS No. : 38230-32-9 Biological Activity：Dehydrocurdione, a zedoary-derived sesquiterpene, induces heme oxygenase (HO)-1, an antioxidative enzyme, in RAW 264.7 macrophages. Dehydrocurdione interacts with Keap1, resulting in Nrf2 translocation followed by activation of the HO-1 E2 enhancer. Dehydrocurdione suppresses lipopolysaccharide-induced NO release, a marker of […]

For research use only. We do not sell to patients. Cabozantinib S-malate CAS No. : 1140909-48-3 Biological Activity：Cabozantinib S-malate (XL184 S-malate) is a potent multiple receptor tyrosine kinases inhibitor that inhibits VEGFR2, c-Met, Kit, Axl and Flt3 with IC50s of 0.035, 1.3, 4.6, 7 and 11.3 nM, respectively. Research Area：Cancer Targets：VEGFR|Apoptosis Related Screening Libraries:Drug Repurposing […]

For research use only. We do not sell to patients. Nimodipine CAS No. : 66085-59-4 Biological Activity：Nimodipine (BAY-e 9736) is an orally active, well-tolerated and light-sensitive dihydropyridine calcium antagonist. Nimodipine can be used for the research of cerebrovascular disorders. Research Area：Cardiovascular Disease|Cancer Targets：Autophagy|Calcium Channel Related Screening Libraries:Drug Repurposing Compound Library Plus; FDA-Approved Drug Library Plus;FDA-Approved […]

For research use only. We do not sell to patients. Hydrochlorothiazid-d2 CAS No. : 1219798-89-6 Biological Activity：Hydrochlorothiazid-d2 (HCTZ-d2) is the deuterium labeled Hydrochlorothiazide. Hydrochlorothiazide (HCTZ), an orally active diuretic drug of the thiazide class, inhibits transforming TGF-β/Smad signaling pathway. Hydrochlorothiazide has direct vascular relaxant effects via opening of the calcium-activated potassium (KCA) channel. Hydrochlorothiazide improves […]