Tag: Activator|Inhibitor

For research use only. We do not sell to patients. TD52 CAS No. : 1798328-24-1 Biological Activity：TD52, an Erlotinib (HY-50896) derivative, is an orally active, potent cancerous inhibitor of protein phosphatase 2A (CIP2A) inhibitor. TD52 mediates the apoptotic effect in triple-negative breast cancer (TNBC) cells via regulating the CIP2A/PP2A/p-Akt signalling pathway. TD52 indirectly reduced CIP2A […]

For research use only. We do not sell to patients. Rhosin hydrochloride CAS No. : 1281870-42-5 Biological Activity：Rhosin hydrochloride is a potent, specific RhoA subfamily Rho GTPases inhibitor. Rhosin hydrochloride specifically binds to RhoA to inhibit RhoA-GEF interaction with a Kd of ~ 0.4 uM, and does not interact with Cdc42 or Rac1, nor the […]

For research use only. We do not sell to patients. Lapatinib CAS No. : 231277-92-2 Biological Activity：Lapatinib (GW572016) is a potent inhibitor of the ErbB-2 and EGFR tyrosine kinase domains with IC50 values against purified EGFR and ErbB-2 of 10.2 and 9.8 nM, respectively. Research Area：Cancer Targets：EGFR|Ferroptosis|Autophagy Related Screening Libraries:Covalent Screening Library Plus;Drug Repurposing Compound […]

For research use only. We do not sell to patients. Pictilisib dimethanesulfonate CAS No. : 957054-33-0 Biological Activity：Pictilisib dimethanesulfonate (GDC-0941 dimethanesulfonate) is a potent inhibitor of PI3Kα/δ with IC50 of 3 nM, with modest selectivity against p110β (11-fold) and p110γ (25-fold). Research Area：Cancer Targets：Autophagy|Apoptosis|PI3K Related Screening Libraries:Drug Repurposing Compound Library Plus;Clinical Compound Library Plus;Bioactive Compound […]

For research use only. We do not sell to patients. HLCL-61 hydrochloride CAS No. : 1158279-20-9 Biological Activity：HLCL-61 hydrochloride is a first-in-class inhibitor of protein arginine methyltransferase 5 (PRMT5). Research Area：Cancer Targets：Histone Methyltransferase|Apoptosis Related Screening Libraries:Bioactive Compound Library Plus;Apoptosis Compound Library;Epigenetics Compound Library;Histone Modification Research Compound Library;Anti-Cancer Compound Library;Reprogramming Compound Library;Anti-diabetic Compound Library;Anti-Blood Cancer Compound […]

For research use only. We do not sell to patients. Brivanib (alaninate) CAS No. : 649735-63-7 Biological Activity：Brivanib alaninate (BMS-582664) is an ATP-competitive inhibitor against VEGFR2 with an IC50 of 25 nM; has moderate potency against VEGFR-1 and FGFR-1, but more than 240-fold against PDGFRβ. Research Area：Cancer Targets：Autophagy|VEGFR Related Screening Libraries:Drug Repurposing Compound Library Plus;Clinical […]

For research use only. We do not sell to patients. G5-7 CAS No. : 939681-36-4 Biological Activity：G5-7, an orally active and allosteric JAK2 inhibitor, selectively inhibits JAK2 mediated phosphorylation and activation of EGFR (Tyr1068) and STAT3 by binding to JAK2. G5-7 induces cell cycle arrest, apoptosis and possesses antiangiogenic effect. G5-7 has the potential for […]

For research use only. We do not sell to patients. 1-Deoxynojirimycin CAS No. : 19130-96-2 Biological Activity：1-Deoxynojirimycin (Duvoglustat) is a potent and orally active α-glucosidase inhibitor. 1-Deoxynojirimycin suppresses postprandial blood glucose and is widely used for diabetes mellitus. 1-Deoxynojirimycin possesses antihyperglycemic, anti-obesity, and antiviral features[2]. Research Area：Metabolic Disease Targets：Glucosidase|PI3K Related Screening Libraries:Natural Product Library Plus;Drug […]

For research use only. We do not sell to patients. TPCA-1 CAS No. : 507475-17-4 Biological Activity：TPCA-1 is a potent and selective inhibitor of IKK-2 with IC50 of 17.9 nM. TPCA-1 is an effective inhibitor of STAT3 phosphorylation, DNA binding, and transactivation. Research Area：Inflammation/Immunology|Cancer Targets：STAT|IKK|Apoptosis Related Screening Libraries:Bioactive Compound Library Plus;Apoptosis Compound Library;Immunology/Inflammation Compound Library;JAK/STAT […]

For research use only. We do not sell to patients. DCH36_06 CAS No. : 593273-05-3 Biological Activity：DCH36_06 is a potent and selective p300/CBP inhibitor with IC50s of 0.6 μM and 3.2 μM for p300 and CBP, respectively. DCH36_06 mediated p300/CBP inhibition leading to hypoacetylation on H3K18 in leukemic cells. Anti-tumor activity. Research Area：Cancer Targets：Apoptosis|Histone Acetyltransferase […]