Tag: Activator|Inhibitor

For research use only. We do not sell to patients. BO-264 CAS No. : 2408648-20-2 Biological Activity：BO-264 is a highly potent and orally active transforming acidic coiled-coil 3 (TACC3) inhibitor with an IC50 of 188 nM and a Kd of 1.5 nM. BO-264 specifically blocks the function of FGFR3-TACC3 fusion protein. BO-264 induces spindle assembly […]

For research use only. We do not sell to patients. BMS-833923 CAS No. : 1059734-66-5 Biological Activity：BMS-833923 (XL-139) is an orally bioavailable small-molecule inhibitor of Smoothened with potential antineoplastic activity; inhibits BODIPY cyclopamine binding to SMO in a dose-dependent manner with an IC50 of 21 nM. IC50 Value: 6-35 nM [1] Target: Smoothened SMO antagonist […]

For research use only. We do not sell to patients. RWJ-56110 CAS No. : 252889-88-6 Biological Activity：RWJ-56110 is a potent, selective, peptide-mimetic inhibitor of PAR-1 activation and internalization (binding IC50=0.44 uM) and shows no effect on PAR-2, PAR-3, or PAR-4. RWJ-56110 inhibits the aggregation of human platelets induced by both SFLLRN-NH2 (IC50=0.16 μM) and thrombin (IC50=0.34 μM), quite […]

For research use only. We do not sell to patients. NecroIr1 Biological Activity：NecroIr1 is an iridium(III) complex, serves as necroptosis inducers in Cisplatin (HY-17394)-resistant lung cancer cells (A549R). NecroIr1 selectively accumulates in mitochondria, leading to oxidative stress and loss of mitochondrial membrane potential (MMP). NecroIr1 activates receptor-interacting serine-threonine kinase 3 (RIPK3) and Mixed Lineage Kinase […]

For research use only. We do not sell to patients. Seneciphylline CAS No. : 480-81-9 Biological Activity：Seneciphylline is a toxic pyrrolizidine alkaloid in Gynura japonica. Seneciphylline significantly increases the activities of epoxide hydrase and glutathione-S-transferase but causes reduction of cytochrome P-450 and related monooxygenase activities[2]. Research Area：Cancer Targets：Gutathione S-transferase|Cytochrome P450 Related Screening Libraries:Natural Product Library […]

For research use only. We do not sell to patients. Mivebresib CAS No. : 1445993-26-9 Biological Activity：Mivebresib (ABBV-075) is a potent and orally active bromodomain and extraterminal domain (BET) bromodomain inhibitor. Mivebresib binds to BRD4 with a Ki of 1.5 nM. Research Area：Cancer Targets：Epigenetic Reader Domain|Apoptosis Related Screening Libraries:Clinical Compound Library Plus;Bioactive Compound Library Plus;Apoptosis […]

For research use only. We do not sell to patients. Danusertib CAS No. : 827318-97-8 Biological Activity：Danusertib is a pyrrolo-pyrazole and aurora kinase inhibitor with IC50 of 13, 79, and 61 nM for Aurora A, B, and C, respectively. Research Area：Cancer Targets：Autophagy|Aurora Kinase Related Screening Libraries:Drug Repurposing Compound Library Plus;Clinical Compound Library Plus;Bioactive Compound Library […]

For research use only. We do not sell to patients. ζ-Stat trisodium CAS No. : 31894-34-5 Biological Activity：ζ-Stat trisodium (NSC37044 trisodium) is a specific and atypical PKC-ζ inhibitor, with an IC50 of 5 μM. ζ-Stat trisodium can reduce melanoma cell lines proliferation and induce apoptosis, and has antitumor activity in vitro[2]. Research Area：Cancer Targets：PKC|Apoptosis Related […]

For research use only. We do not sell to patients. 8-CPT-Cyclic AMP sodium CAS No. : 93882-12-3 Biological Activity：8-CPT-Cyclic AMP (8-CPT-cAMP) sodium is a selective activator of cyclic AMP-dependent protein kinase (PKA). 8-CPT-Cyclic AMP sodium is also a potent inhibitor of the cyclic GMP-specific phosphodiesterase (PDE VA) with an IC50 of 0.9 μM. 8-CPT-Cyclic AMP […]

For research use only. We do not sell to patients. Selonsertib CAS No. : 1448428-04-3 Biological Activity：Selonsertib (GS-4997), an orally bioavailable, selective apoptosis signal-regulating kinase 1 (ASK1) inhibitor with a pIC50 of 8.3, has been evaluated as an experimental treatment for diabetic nephropathy and kidney fibrosis. Research Area：Cancer Targets：MAP3K|Apoptosis Related Screening Libraries:Drug Repurposing Compound Library […]