Tag: Activator|Inhibitor

For research use only. We do not sell to patients. Prexasertib Mesylate Hydrate CAS No. : 1234015-57-6 Biological Activity：Prexasertib Mesylate Hydrate (LY2606368 Mesylate Hydrate) is a selective, ATP-competitive second-generation checkpoint kinase 1 (CHK1) inhibitor with a Ki of 0.9 nM and an IC50 of

For research use only. We do not sell to patients. XL019 CAS No. : 945755-56-6 Biological Activity：XL019 is a potent, orally active, and selective JAK2 inhibitor, with IC50s of 2.2, 134.3, and 214.2 nM for JAK2, JAK1 and JAK3, respectively. XL019 shows 50-fold or greater selectivity for JAK2, versus a panel of over 100 serine/threonine and […]

For research use only. We do not sell to patients. Imeglimin CAS No. : 775351-65-0 Biological Activity：Imeglimin (EMD 387008) is an oral glucose-lowering agent. Imeglimin improves insulin sensitivity. Imeglimin also reduces reactive oxygen species (ROS) production, increases mitochondrial DNA and improves mitochondrial function. Research Area：Metabolic Disease Targets：Reactive Oxygen Species|Mitochondrial Metabolism Related Small Molecules:D-α-Hydroxyglutaric acid disodium;Chitoheptaose […]

For research use only. We do not sell to patients. Domatinostat tosylate CAS No. : 1186222-89-8 Biological Activity：Domatinostat tosylate (4SC-202) is a selective class I HDAC inhibitor with IC50 of 1.20 μM, 1.12 μM, and 0.57 μM for HDAC1, HDAC2, and HDAC3, respectively. It also displays inhibitory activity against Lysine specific demethylase 1 (LSD1). Research […]

For research use only. We do not sell to patients. PD0166285 dihydrochloride CAS No. : 212391-63-4 Biological Activity：PD0166285 dihydrochloride, a substrate of P-gp, is a WEE1 inhibitor and a weak Myt1 inhibitor with IC50 values of 24 and 72 nM, respectively. PD0166285 dihydrochloride exhibits an IC50 of 3.433 μM for Chk1. Research Area：Cancer Targets：Wee1|Apoptosis Related […]

For research use only. We do not sell to patients. Withaferin A CAS No. : 5119-48-2 Biological Activity：Withaferin A is a steroidal lactone isolated from Withania somnifera, inhibits NF-kB activation and targets vimentin, with potent antiinflammatory and anticancer activities. Withaferin A is an inhibitor of endothelial protein C receptor (EPCR) shedding. Research Area：Cancer|Inflammation/Immunology Targets：Ferroptosis|NF-κB Related […]

For research use only. We do not sell to patients. Nitrendipine CAS No. : 39562-70-4 Biological Activity：Nitrendipine (BAY-E-5009), an analogue of Nifedipine (HY-B0284), is a dihydropyridine calcium channel blocker with vasodilator action. Nitrendipine has antihypertensive effect[2][3][4]. Research Area：Cardiovascular Disease Targets：Autophagy|Calcium Channel Related Screening Libraries:Drug Repurposing Compound Library Plus;FDA-Approved Drug Library Plus;FDA-Approved Drug Library Mini;Bioactive Compound […]

For research use only. We do not sell to patients. Deoxyshikonin CAS No. : 43043-74-9 Biological Activity：Deoxyshikonin is isolated from Arnebia euchroma with antitumor activity. Deoxyshikonin increases the expression of VEGF-C and VEGF-A mRNA in HMVEC-dLy, promotes HIF-1α and HIF-1β subunit interaction and binds to specific DNA sequences targeted by HIF, indicates a prolymphangiogenesis as […]

For research use only. We do not sell to patients. Eicosatetraynoic acid CAS No. : 1191-85-1 Biological Activity：Eicosatetraynoic acid (ETYA) is a nonspecific inhibitor of cyclooxygenase and lipoxygenase (ID50=8 μM and 4 μM, respectively). Eicosatetraynoic acid (ETYA) activates PPARα and PPARγ chimeras at 10 µM[2]. Eicosatetraynoic acid specifically interferes with the replication of the cowpox […]

For research use only. We do not sell to patients. OTS964 CAS No. : 1338542-14-5 Biological Activity：OTS964 is an orally active, high affinity and selective TOPK inhibitor with an IC50 of 28 nM. OTS964 is also a potent inhibitor of the cyclin-dependent kinase CDK11, which binds to CDK11B with a Kd of 40 nM[2]. Research […]