Tag: Activator|Inhibitor

For research use only. We do not sell to patients. PIK-75 CAS No. : 372196-67-3 Biological Activity：PIK-75 is a reversible DNA-PK and p110α-selective inhibitor, which inhibits DNA-PK, p110α and p110γ with IC50s of 2, 5.8 and 76 nM, respectively. PIK-75 inhibits p110α >200-fold more potently than p110β (IC50=1.3 μM)[2]. PIK-75 induces apoptosis[3]. Research Area：Cancer Targets：DNA-PK|Apoptosis|PI3K […]

For research use only. We do not sell to patients. FTI-277 hydrochloride CAS No. : 180977-34-8 Biological Activity：FTI-277 hydrochloride is an inhibitor of farnesyl transferase (FTase); a highly potent Ras CAAX peptidomimetic which antagonizes both H- and K-Ras oncogenic signaling. FTI-277 hydrochloride can inhibit hepatitis delta virus (HDV) infection. Research Area：Cancer|Infection Targets：Farnesyl Transferase|Apoptosis|Ras Related Screening […]

For research use only. We do not sell to patients. Licochalcone B CAS No. : 58749-23-8 Biological Activity：Licochalcone B is an extract from the root of Glycyrrhiza uralensis. Licochalcone B inhibits amyloid β (42) self-aggregation (IC50=2.16 μM) and disaggregate pre-formed Aβ42 fibrils, reduce metal-induced Aβ42 aggregation through chelating metal ionsLicochalcone B inhibits phosphorylation of NF-κB […]

For research use only. We do not sell to patients. Astilbin CAS No. : 29838-67-3 Biological Activity：Astilbin is a flavonoid compound and enhances NRF2 activation. Astilbin also suppresses TNF-α expression and NF-κB activation. Research Area：Inflammation/Immunology|Cancer Targets：TNF Receptor|Keap1-Nrf2|NF-κB Related Screening Libraries:Natural Product Library Plus;Bioactive Compound Library Plus;Apoptosis Compound Library;Immunology/Inflammation Compound Library;NF-κB Signaling Compound Library;Stem Cell Signaling […]

For research use only. We do not sell to patients. GSK-1070916 CAS No. : 942918-07-2 Biological Activity：GSK-1070916 is a potent and selective ATP-competitive inhibitor of aurora B and aurora C with Kis of 0.38 and 1.5 nM, respectively, and is >250- fold selective over Aurora A. Research Area：Cancer Targets：Aurora Kinase|Apoptosis Related Screening Libraries:Clinical Compound Library […]

For research use only. We do not sell to patients. Nirogacestat dihydrobromide CAS No. : 1962925-29-6 Biological Activity：Nirogacestat dihydrobromide (PF-3084014 dihydrobromide) is a reversible, orally bioavailable, noncompetitive, and selective γ-secretase inhibitor with an IC50 of 6.2 nM. Inhibition of Notch signaling by Nirogacestat dihydrobromide while minimizing gastrointestinal toxicity presents a promising approach for research of […]

For research use only. We do not sell to patients. EGFR/BRAFV600E-IN-1 CAS No. : 2492429-45-3 Biological Activity：EGFR/BRAFV600E-IN-1 (Compound 23) is a potent EGFR and BRAFV600E dual inhibitor with IC50s of 0.08 and 0.15 µM, respectively. EGFR/BRAFV600E-IN-1 induces apoptosis and cell cycle arrest in both pre-G1 and G2/M phases. EGFR/BRAFV600E-IN-1 exhibits antiproliferative activity againist A-549, MCF-7, […]

For research use only. We do not sell to patients. Nepodin CAS No. : 3785-24-8 Biological Activity：Nepodin (Musizin) is a quinone oxidoreductase (PfNDH2) inhibitor isolate from Rumex crispus.Nepodin (Musizin) stimulates the translocation of GLUT4 to the plasma membrane by activation of AMPK[2].Nepodin (Musizin) has antidiabetic and antimalarial activities. Research Area：Infection Targets：Parasite|AMPK Related Screening Libraries:Natural Product […]

For research use only. We do not sell to patients. Idelalisib D5 CAS No. : 1830330-31-8 Biological Activity：Idelalisib D5 is a deuterium labeled Idelalisib. Idelalisib is a highly selective and orally bioavailable p110δ inhibitor. Research Area：Cancer Targets：Autophagy|PI3K Related Small Molecules:Umbralisib hydrochloride;Topoisomerase I/II inhibitor 3;Rigosertib sodium;Tenalisib R Enantiomer;PI3kδ inhibitor 1;PI3K/VEGFR2-IN-1;1,3-Dicaffeoylquinic acid;PI3Kδ-IN-1;PI-103-d8;PI3Kα-IN-8;PI-103 Hydrochloride;IC-87114;PI3K/mTOR Inhibitor-6;PI3K-IN-10;SF2523;PI3K-IN-29;PI3K/mTOR Inhibitor-1;PI3K-IN-26;GSK-F1;Serabelisib;Amdizalisib;Glaucocalyxin A;PI3K/AKT-IN-2;PIK-294;CAL-130 Hydrochloride;YS-49;hSMG-1 […]

For research use only. We do not sell to patients. RA-9 CAS No. : 919091-63-7 Biological Activity：RA-9 is a potent and selective proteasome-associated deubiquitinating enzymes (DUBs) inhibitor with favorable toxicity profile and anticancer activity. RA-9 blocks ubiquitin-dependent protein degradation without impacting 20S proteasome proteolytic activity. RA-9 selectively induces onset of apoptosis in ovarian cancer cell […]