Tag: Activator|Inhibitor

For research use only. We do not sell to patients. (S)-(+)-Rolipram CAS No. : 85416-73-5 Biological Activity：(S)-(+)-Rolipram ((+)-Rolipram) is a cyclic AMP(cAMP)-specific phosphodiesterase 4 (PDE4) inhibitor, with an IC50 of 1100 nM. (S)-(+)-Rolipram can suppresse tumor necrosis factor-alpha (TNFα) production by human mononuclear cells[2][3]. Research Area：Cancer|Inflammation/Immunology|Neurological Disease Targets：Phosphodiesterase (PDE)|Apoptosis Related Screening Libraries:Bioactive Compound Library Plus;Apoptosis […]

For research use only. We do not sell to patients. SMIP004 CAS No. : 143360-00-3 Biological Activity：SMIP004 is a SKP2 E3 ligase inhibitor, which downregulates SKP2 and to stabilise p27. SMIP004 is a cancer cell selective apoptosis inducer of human prostate cancer cells[2]. Research Area：Cancer Targets：Apoptosis|E1/E2/E3 Enzyme Related Screening Libraries:Bioactive Compound Library Plus;Apoptosis Compound Library;Metabolism/Protease […]

For research use only. We do not sell to patients. RHPS4 CAS No. : 390362-78-4 Biological Activity：RHPS4 is a potent telomerase inhibitor (IC50 = 0.33 μM). RHPS4 is a DNA damage inducer[2]. Research Area：Cancer Targets：Telomerase|Apoptosis Related Screening Libraries:Bioactive Compound Library Plus; Related Small Molecules:Physalin A;Bomedemstat ditosylate;Enpp/Carbonic anhydrase-IN-1;GK563;Calpeptin;Lobetyolin;BJE6-106;Dinaciclib;Ecteinascidin 770;MDM2-p53-IN-15;AT9283;Staurosporine;SNS-032;C188-9;ZLDI-8;Topoisomerase I/II inhibitor 3;Xevinapant;Mangiferin;Cambinol;Antioxidant agent-5;Apoptosis inducer 9;Bafetinib;Cyclovirobuxine D;STAT3-IN-10;Rigosertib […]

For research use only. We do not sell to patients. DEL-22379 CAS No. : 181223-80-3 Biological Activity：DEL-22379 is an ERK dimerization Inhibitor. DEL-22379 readily binds to ERK2 with a Kd estimated in the low micromolar range, though binding is detectable even at low nanomolar concentrations. ERK2 dimerization is progressively inhibited with an IC50 of ~0.5 […]

For research use only. We do not sell to patients. RWJ-56110 dihydrochloride CAS No. : 2387505-58-8 Biological Activity：RWJ-56110 dihydrochloride is a potent, selective, peptide-mimetic inhibitor of PAR-1 activation and internalization (binding IC50=0.44 uM) and shows no effect on PAR-2, PAR-3, or PAR-4. RWJ-56110 dihydrochloride inhibits the aggregation of human platelets induced by both SFLLRN-NH2 (IC50=0.16 μM) and thrombin […]

For research use only. We do not sell to patients. SSE15206 CAS No. : 1370046-40-4 Biological Activity：SSE15206 is a microtubule polymerization inhibitor (GI50 = 197 nM in HCT116 cells) that overcomes multidrug resistance. Causes aberrant mitosis resulting in G2/M arrest due to incomplete spindle formation in cancer cells. Research Area：Cancer Targets：Microtubule/Tubulin|Apoptosis Related Screening Libraries:Bioactive Compound […]

For research use only. We do not sell to patients. Monalizumab CAS No. : 1228763-95-8 Biological Activity：Monalizumab is a first-in-class immune checkpoint inhibitor targeting Natural Killer Group 2A (NKG2A). Monalizumab, a humanized anti-NKG2A blocking mAb, increases IFN-γ production, thereby promoting NK cell effector functions. Monalizumab can be used for the research of head and neck […]

For research use only. We do not sell to patients. Sacubitril/Valsartan CAS No. : 936623-90-4 Biological Activity：Sacubitril/Valsartan (LCZ696), comprised Valsartan and Sacubitril (AHU377) in 1:1 molar ratio, is a first-in-class, orally bioavailable, and dual-acting angiotensin receptor-neprilysin (ARN) inhibitor for hypertension and heart failure[2][3]. Sacubitril/Valsartan ameliorates diabetic cardiomyopathy by inhibiting inflammation, oxidative stress and apoptosis[4]. Research […]

For research use only. We do not sell to patients. R406 free base CAS No. : 841290-80-0 Biological Activity：R406 free base is an orally available and competitive Syk/FLT3 inhibitor for ATP binding with a Ki of 30 nM, potently inhibits Syk kinase activity in vitro with an IC50 of 41 nM, measured at an ATP […]

For research use only. We do not sell to patients. KY19382 CAS No. : 2226664-93-1 Biological Activity：KY19382 is a potent and orally active dual inhibitor of CXXC5-DVL and GSK3β, with IC50s of 19 and 10 nM, respectively. KY19382 activates Wnt/β-catenin signaling through inhibitory effects on both CXXC5-DVL interaction and GSK3β activity. KY19382 can be used […]