Tag: Activator|Inhibitor

For research use only. We do not sell to patients. YZ129 CAS No. : 1643120-60-8 Biological Activity：YZ129 is an inhibitor of the HSP90-calcineurin-NFAT pathway against glioblastoma, directly binding to heat shock protein 90 (HSP90) with an IC50 of 820 nM on NFAT nuclear translocation. YZ129-induced GBM cell-cycle arrest at the G2/M phase promotes apoptosis and […]

For research use only. We do not sell to patients. Kurarinol CAS No. : 855746-98-4 Biological Activity：Kurarinol is a flavanone found in the root of Sophora flavescens. Kurarinol is a competitive tyrosinase inhibitor, with IC50 of 0.1 μM for mushroom tyrosinase. Research Area：Cancer|Cardiovascular Disease Targets：Tyrosinase|Apoptosis Related Small Molecules:Physalin A;Bomedemstat ditosylate;Enpp/Carbonic anhydrase-IN-1;GK563;Calpeptin;Lobetyolin;BJE6-106;Dinaciclib;Ecteinascidin 770;MDM2-p53-IN-15;AT9283;Staurosporine;SNS-032;C188-9;ZLDI-8;Topoisomerase I/II inhibitor 3;Xevinapant;Mangiferin;Cambinol;Antioxidant […]

For research use only. We do not sell to patients. Oxcarbazepine CAS No. : 28721-07-5 Biological Activity：Oxcarbazepine is a sodium channel blocker. Oxcarbazepine significantly inhibits glioblastoma cell growth and induces apoptosis or G2/M arrest in glioblastoma cell lines[2]. Anti-cancer and anticonvulsant effects[2][3]. Research Area：Cancer|Neurological Disease Targets：Sodium Channel|Apoptosis Related Screening Libraries:Drug Repurposing Compound Library Plus;FDA-Approved Drug […]

For research use only. We do not sell to patients. NU 7026 CAS No. : 154447-35-5 Biological Activity：NU 7026 (LY293646) is a novel specific DNA-PK inhibitor with IC50 of 0.23 μM, also inhibits PI3K with IC50 of 13 μM. Research Area：Cancer Targets：DNA-PK|Apoptosis Related Screening Libraries:Bioactive Compound Library Plus;Apoptosis Compound Library;Cell Cycle/DNA Damage Compound Library;Kinase Inhibitor […]

For research use only. We do not sell to patients. Selamectin CAS No. : 220119-17-5 Biological Activity：Selamectin, a semi-synthetic macrocyclic lactone, is a potent parasiticide and anthelminthic. Selamectin activates glutamate-gated chloride channels in neurons and pharyngeal muscles to prevent heartworm, Lymphatic filariae, and nematode infection. Selamectin is also a potent P-glycoprotein substrate and a P-glycoprotein […]

For research use only. We do not sell to patients. PD168393 CAS No. : 194423-15-9 Biological Activity：PD168393 is a potent, selective and cell-permeable inhibitor of EGFR tyrosine kinase and ErbB2. PD168393 irreversiblely inactivates EGF receptor ( IC50=0.7 nM) and is inactive against insulin receptor, PDGFR, FGFR and PKC. Research Area：Cancer Targets：EGFR|Autophagy|Apoptosis Related Screening Libraries:Covalent Screening Library […]

For research use only. We do not sell to patients. Sp-cAMPS sodium salt CAS No. : 142439-95-0 Biological Activity：Sp-cAMPS sodium salt, a cAMP analog, is potent activator of cAMP-dependent PKA I and PKA II. Sp-cAMPS sodium salt is also a potent, competitive phosphodiesterase (PDE3A) inhibitor with a Ki of 47.6 µM. Sp-cAMPS sodium salt binds […]

For research use only. We do not sell to patients. CPI-203 CAS No. : 1446144-04-2 Biological Activity：CPI-203 is a novel potent, selective and cell permeable inhibitor of BET bromodomain, with an IC50 value of appr 37 nM (BRD4 α-screen assay). Research Area：Cancer Targets：Epigenetic Reader Domain|Apoptosis Related Screening Libraries:Bioactive Compound Library Plus;Apoptosis Compound Library;Epigenetics Compound Library;Histone […]

For research use only. We do not sell to patients. Lovastatin CAS No. : 75330-75-5 Biological Activity：Lovastatin is a cell-permeable HMG-CoA reductase inhibitor used to lower cholesterol. Research Area：Cardiovascular Disease|Cancer Targets：Ferroptosis|Autophagy|HMG-CoA Reductase (HMGCR) Related Screening Libraries:Covalent Screening Library Plus;Natural Product Library Plus;Drug Repurposing Compound Library Plus;FDA-Approved Drug Library Plus;FDA-Approved Drug Library Mini;Bioactive Compound Library Plus;Apoptosis […]

For research use only. We do not sell to patients. Ricolinostat CAS No. : 1316214-52-4 Biological Activity：Ricolinostat (ACY-1215) is a potent and selective HDAC6 inhibitor, with an IC50 of 5 nM. ACY-1215 also inhibits HDAC1, HDAC2, and HDAC3 with IC50s of 58, 48, and 51 nM, respectively. Research Area：Cancer Targets：HDAC|Apoptosis Related Screening Libraries:Drug Repurposing Compound […]