Tag: Activator|Antagonist

For research use only. We do not sell to patients. Capsazepine CAS No. : 138977-28-3 Biological Activity：Capsazepine is a synthetic analogue of the sensory neurone excitotoxin, and an antagonist of TRPV1 receptor with an IC50 of 562 nM. Research Area：Cancer Targets：TRP Channel|Apoptosis Related Screening Libraries:Bioactive Compound Library Plus;Apoptosis Compound Library;Membrane Transporter/Ion Channel Compound Library;Neuronal Signaling […]

For research use only. We do not sell to patients. GYKI-47261 dihydrochloride CAS No. : 1217049-32-5 Biological Activity：GYKI-47261 dihydrochloride is a competitive, orally active, and selective AMPA receptor antagonist with an IC50 of 2.5 μM. GYKI-47261 has broad spectrum anticonvulsive activity and neuroprotective effects. GYKI-47261 dihydrochloride is also a potent inducer of CYP2E1[2]. Research Area：Neurological […]

For research use only. We do not sell to patients. CRTh2 antagonist 3 CAS No. : 312928-72-6 Biological Activity：CRTh2 antagonist 3 is a potent chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTh2) antagonist. CRTh2 antagonist 3 enhances the activity of PDK1 toward a short peptide substrate, with an EC50 of 2 μM and a Kd […]

For research use only. We do not sell to patients. UNC1215 CAS No. : 1415800-43-9 Biological Activity：UNC1215 is a potent and selective inhibitor for the methyllysine (Kme) reading domain function of L3MBTL3 with a Kd value of 120 nM and an IC50 of 40 nM. UNC1215 has the potential to treat malignant brain tumor. Research […]

For research use only. We do not sell to patients. TP508 CAS No. : 121341-81-9 Biological Activity：TP508 is a 23-amino acid nonproteolytic thrombin peptide that represents a portion of the receptor-binding domain of thrombin molecule. TP508 activates endothelial NO synthase (eNOS) and stimulates production of NO in human endothelial cells. TP508 activates endothelial cells and […]

For research use only. We do not sell to patients. LE135 CAS No. : 155877-83-1 Biological Activity：LE135 is a potent RAR antagonist that binds selectively to RARα (Ki of 1.4 μM) and RARβ (Ki of 220 nM), and has a higher affinity to RARβ. LE135 is highly selective over RARγ, RXRα, RXRβ and RXRγ. LE135 […]

For research use only. We do not sell to patients. Celiprolol hydrochloride CAS No. : 57470-78-7 Biological Activity：Celiprolol (REV 5320) is a potent, cardioselective and orally active β1-andrenoceptor r antagonist with partial β2 agonist activity, with Ki values of 0.14-8.3 μM. Celiprolol has antihypertensive and antianginal activity, and can be used for the research of […]

For research use only. We do not sell to patients. Antagonist G CAS No. : 115150-59-9 Biological Activity：Antagonist G is a potent vasopressin antagonist. Antagonist G is also a weak antagonist of GRP and Bradykinin. Antagonist G induces AP-1 transcription and sensitizes cells to chemotherapy[2]. Research Area：Cancer Targets：Apoptosis|Vasopressin Receptor Related Screening Libraries:Bioactive Compound Library Plus;Apoptosis […]

For research use only. We do not sell to patients. Iptakalim hydrochloride CAS No. : 642407-63-4 Biological Activity：Iptakalim hydrochloride, a lipophilic para-amino compound, is a novel ATP-sensitive potassium channel (KATP) opener, as well as an α4β2-containing nicotinic acetylcholine receptor (nAChR) antagonist. Research Area：Neurological Disease Targets：nAChR|Potassium Channel Related Screening Libraries:Bioactive Compound Library Plus;Membrane Transporter/Ion Channel Compound […]

For research use only. We do not sell to patients. AZD5582 CAS No. : 1258392-53-8 Biological Activity：AZD5582 is an antagonist of the inhibitor of apoptosis proteins (IAPs), which binds to the BIR3 domains cIAP1, cIAP2, and XIAP with IC50s of 15, 21, and 15 nM, respectively. AZD5582 induces apoptosis. Research Area：Cancer Targets：IAP|Apoptosis Related Screening Libraries:Bioactive […]