Tag: Activator|Agonist

For research use only. We do not sell to patients. Valerenic acid CAS No. : 3569-10-6 Biological Activity：Valerenic acid ((-)-Valerenic Acid), a sesquiterpenoid, is an orally active positive allosteric modulator of GABAA receptors. Valerenic acid is also a partial agonist of the 5-HT5a receptor. Valerenic acid mediates anxiolytic activity via GABAA receptors containing the β3 […]

For research use only. We do not sell to patients. Dinoprost CAS No. : 551-11-1 Biological Activity：Dinoprost (Prostaglandin F2α) is an orally active, potent prostaglandin F (PGF) receptor (FP receptor) agonist. Dinoprost is a luteolytic hormone produced locally in the endometrial luminal epithelium and corpus luteum (CL). Dinoprost plays a key role in the onset […]

For research use only. We do not sell to patients. GSK2245035 CAS No. : 1207629-49-9 Biological Activity：GSK2245035 is a highly potent and selective intranasal Toll-Like receptor 7 (TLR7) agonist with preferential Type-1 interferon (IFN)-stimulating properties. GSK2245035 has pEC50s of 9.3 and 6.5 for IFNα and TFNα. GSK2245035 effectively suppresses allergen-induced Th2 cytokine production in human […]

For research use only. We do not sell to patients. [Tyr8] Bradykinin CAS No. : 32222-00-7 Biological Activity：[Tyr8] Bradykinin is a B2 kinin receptor agonist. [Tyr8] Bradykinin also stimulates ERK1/2 phosphorylation. [Tyr8] Bradykinin can be used as an internal standard. Research Area：Endocrinology|Cardiovascular Disease Targets：Bradykinin Receptor|ERK Related Small Molecules:Corynoxeine;Temuterkib;CKLF1-C27;LM22B-10;ERK5-IN-4;Pachymic acid;MAP855;Icatibant acetate;Retrobradykinin;6-OAU;VX-11e;Bombinakinin M;Pluripotin;2,5-Dihydroxyacetophenone;Astragaloside IV;ERK1/2 inhibitor 1;Longdaysin;Gypenoside L;ERK-IN-2;Omtriptolide;Bradykinin […]

For research use only. We do not sell to patients. D18 CAS No. : 2230218-36-5 Biological Activity：D18 is an immune modulator. D18 acts as a TLR7/8 dual agonist (EC50=24 nM for hTLR7 and 10 nM for hTLR8, respectively). D18 increases PD-L1 expression through epigenetic regulation, thus sensitizing tumors to PD-1/PD-L1 blockade. D18 is a ADC […]

For research use only. We do not sell to patients. Revexepride CAS No. : 219984-49-3 Biological Activity：Revexepride is a highly selective 5-HT4 receptor agonist, and a potential inducer of CYP3A4 enzyme, used for the treatment of gastroesophageal reflux disease. Research Area：Neurological Disease Targets：5-HT Receptor|Cytochrome P450 Related Screening Libraries:Bioactive Compound Library Plus; Related Small Molecules:F 13714;SR9186;Mosapride-d5;AMG-208;Nuciferine;CYP1B1-IN-1;CYP2C9/CYP2C19-IN-1;Renzapride;Hypericin;LY […]

For research use only. We do not sell to patients. ODN 2216 CAS No. : 332437-00-0 Biological Activity：ODN 2216 is a TLR9 (toll-like receptor 9) ligand or agonist. ODN 2216 induces high amounts of IFN-α and IFN-β. ODN 2216 induces IFN-α by pDC (plasmacytoid DC) and IL-12 (p40) production by DC (dendritic cells). ODN 2216 stimulates IFN-γ […]

For research use only. We do not sell to patients. Adapalene CAS No. : 106685-40-9 Biological Activity：Adapalene (CD271), a third-generation synthetic retinoid, is widely used for the research of acne. Adapalene is a potent RAR agonist, with AC50s of 2.3 nM, 9.3 nM, and 22 nM for RARβ, RARγ, RARα, respectively. Adapalene also inhibits the […]

For research use only. We do not sell to patients. Dinoprost tromethamine salt CAS No. : 38562-01-5 Biological Activity：Dinoprost tromethamine salt (Prostaglandin F2α tromethamine salt) is an orally active, potent prostaglandin F (PGF) receptor (FP receptor) agonist. Dinoprost tromethamine salt is a luteolytic hormone produced locally in the endometrial luminal epithelium and corpus luteum (CL). […]

For research use only. We do not sell to patients. SEW​2871 CAS No. : 256414-75-2 Biological Activity：SEW2871 is an orally active, potent, highly selective S1P1 (sphingosine-1-phosphate type 1 receptor) agonist, with an EC50 of 13.8 nM. SEW2871 activates ERK, Akt, and Rac signaling pathways and induces S1P1 internalization and recycling. SEW2871 reduces lymphocyte numbers in […]