Master of Bioactive Molecules | Inhibitors, Screening Libraries & Proteins
For research use only. We do not sell to patients. Anticancer agent 71 CAS No. : 2453228-45-8 Biological Activity：Anticancer agent 71 (Compound 4b) is a potent anticancer agent and induces apoptosis. Anticancer agent 71 arrests cell cycle at G2/M phase and induces apoptosis through upregulating Bax, Ikb-α and cleaved PARP and downregulating Bcl-2 expression levels. […]
For research use only. We do not sell to patients. SMO-IN-3 CAS No. : 2376914-71-3 Biological Activity：SMO-IN-3 (compound 12a) is a potent smoothened (SMO) inhibitor with an IC50 value of 34.09 nM for hedgehog (Hh) signaling pathway. SMO-IN-3 has antiproliferative activity against human medulloblastoma cell line Daoy. Anticancer activity. Research Area：Cancer Targets：Smo|Hedgehog Related Small Molecules:Saikosaponin […]
For research use only. We do not sell to patients. INCB38579 CAS No. : 1246207-65-7 Biological Activity：INCB38579 is an orally active, highly brain penetrable, and selective histamine H4 receptor (HH4R) antagonist (hH4R IC50=4.8 nM, mH4R IC50=42 nM, rH4R IC50=32 nM). INCB38579 shows anti-inflammatory pain and anti-pruritic activities. Research Area：Infection Targets：Histamine Receptor Related Screening Libraries:Bioactive Compound […]
For research use only. We do not sell to patients. 20S Proteasome-IN-2 CAS No. : 2028300-31-2 Biological Activity：20S Proteasome-IN-2 is a human 20S proteasome inhibitor. 20S Proteasome-IN-2 shows high selectivity to its β5 subunit with the IC50 of 0.18 μM. 20S Proteasome-IN-2 displays anti-proliferative effect in vitro and in vivo, and arrests cell cycle at […]
For research use only. We do not sell to patients. Belinostat CAS No. : 866323-14-0 Biological Activity：Belinostat (PXD101; PX105684) is a potent HDAC inhibitor with an IC50 of 27 nM in HeLa cell extracts. Research Area：Cancer Targets：Autophagy|HDAC Related Screening Libraries:Covalent Screening Library Plus;Drug Repurposing Compound Library Plus;FDA-Approved Drug Library Plus;FDA-Approved Drug Library Mini;Bioactive Compound Library […]
For research use only. We do not sell to patients. 5-Oxoprolyltryptophan CAS No. : 35937-24-7 Biological Activity：5-Oxoprolyltryptophan is a model substrate for investigating the increase of serotonin at the cerebral level. Research Area：Neurological Disease Targets：Others Related Small Molecules:Immune initiator-1;Obiltoxaximab;DIBAC-GGFG-NH2CH2-Dxd;Cyanine5.5 maleimide chloride;Cymarin;Z-Glycine;2-Deoxy-2-fluoro-D-glucose-13C,d7;Water-18O;Fmoc-N-Me-D-Ala-OH;3,5-Diiodo-L-tyrosine;N3-Pen-Dde;Zimeldine-d6;Ornidazole diol;Nylidrin hydrochloride;PFI-653;N-Arachidonoyl Taurine-d4;OVA Peptide (323-339);((3-Fluorophenyl)sulfonyl)glycine;7ß-Hydroxycholesterol-d7;MALAT1-IN-1;Sibiricose A1;Mefruside-d3;Ethacrynic acid mercapturate-d3;FLAG peptide;Neocurdione Trending products：Recombinant Proteins | Bioactive […]
For research use only. We do not sell to patients. Methotrexate α-tert-butyl ester CAS No. : 79640-70-3 Biological Activity：Methotrexate α-tert-butyl ester, capped by OtBu, significantly reduces tumor growth in HT1080 tumor bearing mice. Methotrexate is an antimetabolite and antifolate agent and is also an immunosuppressant and antineoplastic agent[2][3][4]. Research Area：Cancer Targets：DNA/RNA Synthesis|Antifolate Related Small Molecules:Ametantrone;ddCTP […]
For research use only. We do not sell to patients. Guanosine 5′-triphosphate trisodium salt hydrate CAS No. : 207300-85-4 Biological Activity：5′-GTP trisodium salt hydrate is an activator of the signal transducing G proteins and also serves as an energy-rich precursor of mononucleotide units in the enzymatic biosynthesis of DNA and RNA. Research Area：Others Targets：DNA/RNA Synthesis|Endogenous […]
For research use only. We do not sell to patients. SARS-CoV-2-IN-23 disodium Biological Activity：SARS-CoV-2-IN-23 disodium is a two-armed diphosphate ester and medium length molecular tweezers. SARS-CoV-2-IN-23 disodium exhibits antiviral activity with IC50s of 8.2 μM and 2.6 μM against SARS-CoV-2 activity and the spike pseudoparticle transduction, respectively. SARS-CoV-2-IN-23 disodium induces liposomal membrane disruption with an […]
For research use only. We do not sell to patients. LC kinetic stabilizer-2 CAS No. : 2495750-20-2 Biological Activity：LC kinetic stabilizer-2 is a potent amyloidogenic immunoglobulin light chain (LC) kinetic stabilizer with an EC50 of 24 nM. Research Area：Inflammation/Immunology Targets：Others Related Small Molecules:Immune initiator-1;Obiltoxaximab;DIBAC-GGFG-NH2CH2-Dxd;Cyanine5.5 maleimide chloride;Cymarin;Z-Glycine;2-Deoxy-2-fluoro-D-glucose-13C,d7;Water-18O;Fmoc-N-Me-D-Ala-OH;3,5-Diiodo-L-tyrosine;N3-Pen-Dde;Zimeldine-d6;Ornidazole diol;Nylidrin hydrochloride;PFI-653;N-Arachidonoyl Taurine-d4;OVA Peptide (323-339);((3-Fluorophenyl)sulfonyl)glycine;7ß-Hydroxycholesterol-d7;MALAT1-IN-1;Sibiricose A1;Mefruside-d3;Ethacrynic acid mercapturate-d3;FLAG peptide;Neocurdione […]