Product Name :
LIMK2 monoclonal antibody (10E5-19)
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Stable for at least 1 year after receipt when stored at -20°C.
Description:
The LIM kinases 1 and 2 (LIMK1 and LIMK2) are activated downstream of the Rho-ROCK, Rac-PAK, and Cdc42-MRCK pathways, thereby acting as network nodes in the signaling pathways that regulate the actin cytoskeleton. LIMK is required for matrix remodeling activities for path generation by leading cells in collective invasion.
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| Alternative Name LIM domain kinase 2 | Application ICC, IHC (PS), IP, WB | Clone 10E5-19 | Crossreactivity Does not cross-react with LIMK1.{{1610878-71-1} site|{1610878-71-1} Technical Information|{1610878-71-1} In Vivo|{1610878-71-1} manufacturer} | Formulation Liquid.{{113-73-5} web|{113-73-5} Technical Information|{113-73-5} References|{113-73-5} custom synthesis} In PBS containing 10% glycerol and 0.PMID:25905322 02% sodium azide. | Host Rat | Immunogen Recombinant PDZ domain of LIMK2. | Isotype IgG2a | Recommendation Dilutions/Conditions Immunoprecipitation (20ng/ml) , Immunohistochemistry (paraffin sections 10µg/ml) , Immunocytochemistry (10µg/ml) , Western Blot (200ng/ml)Suggested dilutions/conditions may not be available for all applications.Optimal conditions must be determined individually for each application. | Source Purified from concentrated hybridoma tissue culture supernatant. | Species Reactivity Human, Monkey, Mouse | Specificity Recognizes full length endogenous LIMK2. | UniProt ID P53671 | Unit of Measure (UM) µg