Product Name :
IKK-NBD peptide
Sequence:
Asp-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Thr-Ala-Leu-Asp-Trp-Ser-Trp-Leu-Gln-Thr-Glu
Purity:
≥95% (HPLC)
Molecular Weight:
3694.0
Solubility :
Soluble in DMSO (20mM). Note: This peptide will precipitate when added to tissue culture medium, even to 100µM. However, enough will remain in solution to enter many cell types.
Appearance:
Lyophilized solid
Use/Stability :
As indicated on product label or CoA when stored as recommended.
Description:
NF-κB inhibitor The peptide consists of two domains – an antennapedia homeodomain that confers cell permeability and the T735 to E745 region of IKKβ which is the NEMO binding domain (NBD). It is a selective inhibitor of NFκB activation. Blocks interaction of NEMO (an IKB complex regulatory protein) with the IκB kinase complex. The peptide (100 µM) inhibits E-selectin expression in human umbilical vein endothelial cells treated with TNFα and inhibits LPS-induced nitric acid release from a macrophage cell line In an experimental mouse model of acute inflammation, IKK-NBD peptide (topically applied) inhibited PMA induced ear inflammation. Sold under license from Vanderbilt University
CAS :
Solubility:
Soluble in DMSO (20mM).{{83150-76-9} medchemexpress|{83150-76-9} Technical Information|{83150-76-9} Data Sheet|{83150-76-9} manufacturer} Note: This peptide will precipitate when added to tissue culture medium, even to 100µM.{{216974-75-3} site|{216974-75-3} Purity & Documentation|{216974-75-3} Data Sheet|{216974-75-3} custom synthesis} However, enough will remain in solution to enter many cell types.PMID:29939681
Formula:
Additional Information :
| Appearance Lyophilized solid | MW 3694.0 | Purity ≥95% (HPLC) | Sequence Asp-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Thr-Ala-Leu-Asp-Trp-Ser-Trp-Leu-Gln-Thr-Glu | Solubility Soluble in DMSO (20mM). Note: This peptide will precipitate when added to tissue culture medium, even to 100µM. However, enough will remain in solution to enter many cell types.