Product Name :
Ambroxol
Description:
Ambroxol (NA-872), an active metabolite of the prodrug Bromhexine, has potent expectorant effects. Ambroxol is a glucocerebrosidase (GCase) chaperone and increases glucocerebrosidase activity. Ambroxol induces lung autophagy and has the potential for Parkinson disease and neuronopathic Gaucher disease research.
CAS:
18683-91-5
Molecular Weight:
378.10
Formula:
C13H18Br2N2O
Chemical Name:
4-{[(2-amino-3,5-dibromophenyl)methyl]amino}cyclohexan-1-ol
Smiles :
NC1C(Br)=CC(Br)=CC=1CNC1CCC(O)CC1
InChiKey:
JBDGDEWWOUBZPM-UHFFFAOYSA-N
InChi :
InChI=1S/C13H18Br2N2O/c14-9-5-8(13(16)12(15)6-9)7-17-10-1-3-11(18)4-2-10/h5-6,10-11,17-18H,1-4,7,16H2
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Ambroxol (NA-872), an active metabolite of the prodrug Bromhexine, has potent expectorant effects. Ambroxol is a glucocerebrosidase (GCase) chaperone and increases glucocerebrosidase activity. Ambroxol induces lung autophagy and has the potential for Parkinson disease and neuronopathic Gaucher disease research.|Product information|CAS Number: 18683-91-5|Molecular Weight: 378.10|Formula: C13H18Br2N2O|Chemical Name: 4-{[(2-amino-3,5-dibromophenyl)methyl]amino}cyclohexan-1-ol|Smiles: NC1C(Br)=CC(Br)=CC=1CNC1CCC(O)CC1|InChiKey: JBDGDEWWOUBZPM-UHFFFAOYSA-N|InChi: InChI=1S/C13H18Br2N2O/c14-9-5-8(13(16)12(15)6-9)7-17-10-1-3-11(18)4-2-10/h5-6,10-11,17-18H,1-4,7,16H2|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : ≥ 200 mg/mL (528.{{Polatuzumab} web|{Polatuzumab} Antibody-drug Conjugate/ADC Related|{Polatuzumab} Purity & Documentation|{Polatuzumab} References|{Polatuzumab} manufacturer|{Polatuzumab} Epigenetic Reader Domain} 96 mM).{{Andrographolide} site|{Andrographolide} Autophagy|{Andrographolide} Protocol|{Andrographolide} In Vivo|{Andrographolide} manufacturer|{Andrographolide} Autophagy} |Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:31644110 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vivo:|Ambroxol (NA-872; 1, 3, 4, 5 mM for 12 consecutive days in drinking water) results in increased brain glucocerebrosidase activity in wild-type mice, transgenic mice expressing the heterozygous L444P mutation in the murine glucocerebrosidase 1 gene, and transgenic mice overexpressing human α-synuclein.|Products are for research use only. Not for human use.|