Product Name :
UCB-9260
Description:
UCB-9260 is an orally active inhibitor that inhibits TNF signalling by stabilising an asymmetric form of the trimer. UCB-9260 binds TNF with Kd of 13 nM. UCB-9260 also inhibits NF-κB with IC50 of 202 nM after TNF stimulation.
CAS:
1515888-53-5
Molecular Weight:
423.51
Formula:
C26H25N5O
Chemical Name:
(1-(2, 5-dimethylbenzyl)-6-(1-methyl-1H-pyrazol-4-yl)-1H-benzo[d]imidazol-2-yl)(pyridin-4-yl)methanol
Smiles :
CN1C=C(C=N1)C1=CC2=C(C=C1)N=C(C(O)C1C=CN=CC=1)N2CC1=CC(C)=CC=C1C
InChiKey:
RZGFWGNCSYUEPR-UHFFFAOYSA-N
InChi :
InChI=1S/C26H25N5O/c1-17-4-5-18(2)21(12-17)16-31-24-13-20(22-14-28-30(3)15-22)6-7-23(24)29-26(31)25(32)19-8-10-27-11-9-19/h4-15,25,32H,16H2,1-3H3
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Procarbazine} site|{Procarbazine} DNA Alkylator/Crosslinker|{Procarbazine} Purity & Documentation|{Procarbazine} In Vitro|{Procarbazine} supplier|{Procarbazine} Autophagy}
Shelf Life:
≥360 days if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.{{Cofetuzumab pelidotin} web|{Cofetuzumab pelidotin} Inhibitor|{Cofetuzumab pelidotin} TGF-beta/Smad|{Cofetuzumab pelidotin} Purity & Documentation|{Cofetuzumab pelidotin} Data Sheet|{Cofetuzumab pelidotin} custom synthesis}
Additional information:
UCB-9260 is an orally active inhibitor that inhibits TNF signalling by stabilising an asymmetric form of the trimer.PMID:32686511 UCB-9260 binds TNF with Kd of 13 nM. UCB-9260 also inhibits NF-κB with IC50 of 202 nM after TNF stimulation.|Product information|CAS Number: 1515888-53-5|Molecular Weight: 423.51|Formula: C26H25N5O|Chemical Name: (1-(2, 5-dimethylbenzyl)-6-(1-methyl-1H-pyrazol-4-yl)-1H-benzo[d]imidazol-2-yl)(pyridin-4-yl)methanol|Smiles: CN1C=C(C=N1)C1=CC2=C(C=C1)N=C(C(O)C1C=CN=CC=1)N2CC1=CC(C)=CC=C1C|InChiKey: RZGFWGNCSYUEPR-UHFFFAOYSA-N|InChi: InChI=1S/C26H25N5O/c1-17-4-5-18(2)21(12-17)16-31-24-13-20(22-14-28-30(3)15-22)6-7-23(24)29-26(31)25(32)19-8-10-27-11-9-19/h4-15,25,32H,16H2,1-3H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO: 85 mg/mL(200.7 mM).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥360 days if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|References:|James O’Connell, et al. Nat Commun. 2019 Dec 19;10(1):5795.Products are for research use only. Not for human use.|