CRMP2 Rabbit Polyclonal Antibody

Function :
Collapsin response mediator proteins (CRMPs), including CRMP-1 (DRP-1), CRMP-2 (DRP-2 or TOAD64), CRMP-3 (DRP-4), CRMP-4 (DRP-3) and CRMP-5 (DRP-5), mediate signal transduction after exposure of neural cells to the axon guidance molecule Semaphorin 3A (SEMA3A)/collapsin. CRMPs are present in the developing cerebral cortex and neocortical neurons and are responsive to SEMA3A.{{7-Amino-4-methylcoumarin} medchemexpress|{7-Amino-4-methylcoumarin} Others|{7-Amino-4-methylcoumarin} Biological Activity|{7-Amino-4-methylcoumarin} In Vivo|{7-Amino-4-methylcoumarin} supplier|{7-Amino-4-methylcoumarin} Epigenetics} In the adult brain, the expression of CRMPs is dramatically downregulated. However, they remain expressed in structures that retain their capacity for differentiation and plasticity. CRMP-2 is involved in axonal growth and guidance. The human CRMP-2 gene maps to 8p21.2, a chromosomal region that has been previously shown to have a significant linkage to schizophrenia and to several deficit symptoms of schizophrenia.