Product Name :
AZD4635
Description:
AZD-4635, also known as HTL-1071, is an orally available, small molecule adenosine A2A receptor antagonist.
CAS:
1321514-06-0
Molecular Weight:
315.73
Formula:
C15H11ClFN5
Chemical Name:
6-(2-chloro-6-methylpyridin-4-yl)-5-(4-fluorophenyl)-1, 2, 4-triazin-3-amine
Smiles :
CC1=CC(=CC(Cl)=N1)C1=NN=C(N)N=C1C1C=CC(F)=CC=1
InChiKey:
NCWQLHHDGDXIJN-UHFFFAOYSA-N
InChi :
InChI=1S/C15H11ClFN5/c1-8-6-10(7-12(16)19-8)14-13(20-15(18)22-21-14)9-2-4-11(17)5-3-9/h2-7H,1H3,(H2,18,20,22)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Vincristine} medchemexpress|{Vincristine} Apoptosis|{Vincristine} Technical Information|{Vincristine} In Vivo|{Vincristine} supplier|{Vincristine} Cancer}
Shelf Life:
≥12 months if stored properly.{{Canthaxanthin} medchemexpress|{Canthaxanthin} Immunology/Inflammation|{Canthaxanthin} Purity & Documentation|{Canthaxanthin} In Vitro|{Canthaxanthin} manufacturer|{Canthaxanthin} Autophagy}
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:25046520
Additional information:
AZD-4635, also known as HTL-1071, is an orally available, small molecule adenosine A2A receptor antagonist.|Product information|CAS Number: 1321514-06-0|Molecular Weight: 315.73|Formula: C15H11ClFN5|Synonym:|imaradenant|AZD-4635|HTL-1071|Chemical Name: 6-(2-chloro-6-methylpyridin-4-yl)-5-(4-fluorophenyl)-1, 2, 4-triazin-3-amine|Smiles: CC1=CC(=CC(Cl)=N1)C1=NN=C(N)N=C1C1C=CC(F)=CC=1|InChiKey: NCWQLHHDGDXIJN-UHFFFAOYSA-N|InChi: InChI=1S/C15H11ClFN5/c1-8-6-10(7-12(16)19-8)14-13(20-15(18)22-21-14)9-2-4-11(17)5-3-9/h2-7H,1H3,(H2,18,20,22)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : ≥ 83.3 mg/mL (263.83 mM)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|In CHO cells stably expressing human A2AR, the IC50s of AZD4635 for inhibition of cAMP production are 0.79, 10.0 and 142.9 nM in the presense of 0.1, 1 and 10 μM adenosine, respectively.|In Vivo:|Blockade of A2AR signaling with AZD4635 could reduce tumor burden and enhance antitumor immunity.|References:|Alexandra Borodovsky, et al. Abstract 5580: Preclinical pharmacodynamics and antitumor activity of AZD4635, a novel adenosine 2A receptor inhibitor that reverses adenosine mediated T cell suppression. AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 5580.Products are for research use only. Not for human use.|