Product Name :
CREBBP Rabbit Polyclonal Antibody
Predicted band size :
Observed band size :
Synonyms:
CBP antibody CBP_HUMAN antibody CREB binding protein antibody CREB-binding protein antibody Crebbp antibody Cyclic AMP responsive enhancer binding protein antibody KAT3A antibody RSTS antibody RTS antibody Rubinstein Taybi syndrome antibody
Function :
Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like DDX21, FBL, IRF2, MAFG, NCOA3, POLR1E/PAF53 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers. Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER). Acetylates POLR1E/PAF53, leading to decreased association of RNA polymerase I with the rDNA promoter region and coding region .{{Doravirine} site|{Doravirine} Reverse Transcriptase|{Doravirine} Technical Information|{Doravirine} Formula|{Doravirine} custom synthesis|{Doravirine} Autophagy} Acetylates DDX21, thereby inhibiting DDX21 helicase activity.{{Dostarlimab} web|{Dostarlimab} PD-1/PD-L1|{Dostarlimab} Technical Information|{Dostarlimab} References|{Dostarlimab} custom synthesis|{Dostarlimab} Autophagy} Acetylates FBL, preventing methylation of ‘Gln-105’ of histone H2A (H2AQ104me).PMID:23805407 Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway.
Antibody Type:
Rabbit Polyclonal Antibody
Immunogen :
Synthetic peptide within C-terminal human CREBBP.
Species reactivity:
Human, Mouse, Rat
Verify application:
WB, IHC-P
Coupling :
unconjugated
Clone number:
RRID:
AB_3071156
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
Storage buffer solution:
1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Subtype:
IgG
Purification method :
Immunogen affinity purified.
ELTSA :
Molecular weight :
Predicted band size:265 kDa
Positive control :
Human lung carcinoma tissue, mouse cerebellum tissue, rat bladder tissue, rat colon tissue.