COX2/Cyclooxygenase 2 Recombinant Rabbit Monoclonal Antibody [SC56-06]

Function :
Prostaglandins are a diverse group of autocrine and paracrine hormones that mediate many cellular and physiologic processes. Prostaglandin H2 (PGH2) is an intermediate molecule in formation of the prostaglandins.{{Dodecyltrimethylammonium} web|{Dodecyltrimethylammonium} {Biochemical Assay Reagents}|{Dodecyltrimethylammonium} Purity & Documentation|{Dodecyltrimethylammonium} In Vivo|{Dodecyltrimethylammonium} supplier|{Dodecyltrimethylammonium} Epigenetic Reader Domain} Cyclooxygenase-1 (Cox-1) and cyclooxygenase-2 (Cox-2) are prostaglandin synthases that catalyze the formation of PGH2 from arachidonic acid (AA). Cox-1 and Cox-2 are isozymes of prostaglandin-endoperoxidase synthase (PTGS). Cox-1 is constitutively expressed in most tissues and is thought to serve in general “housekeeping” functions. Cox-2 is efficiently induced in migratory cells responding to pro-inflammatory stimuli and is considered to be an important mediator of inflammation.{{AZD5305} MedChemExpress|{AZD5305} Cell Cycle/DNA Damage|{AZD5305} Purity & Documentation|{AZD5305} Data Sheet|{AZD5305} custom synthesis|{AZD5305} Epigenetic Reader Domain} Both enzymes are targets for the nonsteroidal therapeutic anti-inflammatory drugs, NSAIDs.PMID:35670838