CKR-1 Rabbit Polyclonal Antibody

Function :
This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The ligands of this receptor include macrophage inflammatory protein 1 alpha (MIP-1 alpha), regulated on activation normal T expressed and secreted protein (RANTES), monocyte chemoattractant protein 3 (MCP-3), and myeloid progenitor inhibitory factor-1 (MPIF-1). Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation.{{Flecainide} medchemexpress|{Flecainide} Sodium Channel|{Flecainide} Biological Activity|{Flecainide} Purity|{Flecainide} manufacturer|{Flecainide} Autophagy} Knockout studies of the mouse homolog suggested the roles of this gene in host protection from inflammatory response, and susceptibility to virus and parasite.{{MIF Protein, Human} site|{MIF Protein, Human} Technical Information|{MIF Protein, Human} Purity|{MIF Protein, Human} manufacturer|{MIF Protein, Human} Autophagy} This gene and other chemokine receptor genes, including CCR2, CCRL2, CCR3, CCR5 and CCXCR1, are found to form a gene cluster on chromosome 3p.