Product Name :
Fatostatin A — Sterol Regulatory Binding Proteins (SREBPs) Inhibitor
Description:
Fatostatin A is a highly potent, specific and cell permeable inhibitor of Sterol Regulatory Binding Proteins (SREBPs). It inhibits the ER-Golgi translocation of SREBPs via binding to their escort protein (SCAP). It blocks adipogenesis by inhibiting the activation of SREBP-1 and SREBP-2. It exhibits anti-proliferative effects on DU 145 cells independently of IGF-1 signaling (IC50 ~0.1 μM). Fatostatin A can prevent increases in body weight, blood glucose and hepatic fat accumulation and reverses hyperglycemia in diabetic (ob/ob) mice, even under uncontrolled food intake. Fatostatin A may serve as a tool for gaining further insights into the regulation of SREBP.
CAS:
125256-00-0
Molecular Weight:
294.41
Formula:
C18H18N2S
Chemical Name:
2-(2-propylpyridin-4-yl)-4-(p-tolyl)thiazole
Smiles :
CC1C=CC(=CC=1)C1=CSC(=N1)C1=CC(CCC)=NC=C1
InChiKey:
ZROSUBKIGBSZCG-UHFFFAOYSA-N
InChi :
InChI=1S/C18H18N2S/c1-3-4-16-11-15(9-10-19-16)18-20-17(12-21-18)14-7-5-13(2)6-8-14/h5-12H,3-4H2,1-2H3
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Elexacaftor} medchemexpress|{Elexacaftor} CFTR|{Elexacaftor} Protocol|{Elexacaftor} Purity|{Elexacaftor} supplier|{Elexacaftor} Epigenetic Reader Domain}
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Fatostatin A is a highly potent, specific and cell permeable inhibitor of Sterol Regulatory Binding Proteins (SREBPs). It inhibits the ER-Golgi translocation of SREBPs via binding to their escort protein (SCAP). It blocks adipogenesis by inhibiting the activation of SREBP-1 and SREBP-2. It exhibits anti-proliferative effects on DU 145 cells independently of IGF-1 signaling (IC50 ~0.1 μM).{{AZD4573} web|{AZD4573} Inhibitor|{AZD4573} NF-κB|{AZD4573} Purity & Documentation|{AZD4573} References|{AZD4573} custom synthesis} Fatostatin A can prevent increases in body weight, blood glucose and hepatic fat accumulation and reverses hyperglycemia in diabetic (ob/ob) mice, even under uncontrolled food intake. Fatostatin A may serve as a tool for gaining further insights into the regulation of SREBP.|Product information|CAS Number: 125256-00-0|Molecular Weight: 294.41|Formula: C18H18N2S|Related CAS Number:|298197-04-3 (HBr)|Chemical Name: 2-(2-propylpyridin-4-yl)-4-(p-tolyl)thiazole|Smiles: CC1C=CC(=CC=1)C1=CSC(=N1)C1=CC(CCC)=NC=C1|InChiKey: ZROSUBKIGBSZCG-UHFFFAOYSA-N|InChi: InChI=1S/C18H18N2S/c1-3-4-16-11-15(9-10-19-16)18-20-17(12-21-18)14-7-5-13(2)6-8-14/h5-12H,3-4H2,1-2H3|Technical Data|Appearance: Solid Power.|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO up to 50 mM|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:34235739 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined.|HS Tariff Code: 382200|How to use|In Vitro:|Fatostatin A was used at 10-20 µM in vitro.|In Vivo:|Fatostatin A was delivered intraperitoneally at 30 mg/kg once daily for 28 days in ob/ob mice model.|References:|Choi Y, et al. Identification of bioactive molecules by adipogenesis profiling of organic compounds. (2003) J Biol Chem. 278(9):7320-4.Kamisuki S, et al. A small molecule that blocks fat synthesis by inhibiting the activation of SREBP. (2009) Chem Biol. 16(8):882-92.Products are for research use only. Not for human use.|Documents||