Product Name :
CILP Rabbit Polyclonal Antibody
Predicted band size :
Observed band size :
Synonyms:
Cartilage intermediate layer protein 1 antibody Cartilage intermediate layer protein 1 C1 antibody Cartilage intermediate layer protein 1 C2 antibody cartilage intermediate layer protein antibody cartilage intermediate layer protein nucleotide pyrophosphohydrolase antibody Cartilage intermediate-layer protein antibody CILP 1 antibody CILP antibody CILP-1 antibody 展开
Function :
Probably plays a role in cartilage scaffolding. May act by antagonizing TGF-beta1 (TGFB1) and IGF1 functions. Has the ability to suppress IGF1-induced proliferation and sulfated proteoglycan synthesis, and inhibits ligand-induced IGF1R autophosphorylation. May inhibit TGFB1-mediated induction of cartilage matrix genes via its interaction with TGFB1. Overexpression may lead to impair chondrocyte growth and matrix repair and indirectly promote inorganic pyrophosphate (PPi) supersaturation in aging and osteoarthritis cartilage.
Antibody Type:
Rabbit Polyclonal Antibody
Immunogen :
KLH conjugated synthetic peptide derived from human CILP 1051-1184/1184
Species reactivity:
Human, Mouse, Rat, Cow, Horse, Sheep
Verify application:
WB, ELISA, IHC-P, IF, ICC
Coupling :
unconjugated
Clone number:
RRID:
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at -20℃ for one year.{{Ketoprofen} medchemexpress|{Ketoprofen} Immunology/Inflammation|{Ketoprofen} Purity & Documentation|{Ketoprofen} Description|{Ketoprofen} supplier|{Ketoprofen} Cancer} Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20℃. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4℃.
Storage buffer solution:
0.{{Lemzoparlimab} MedChemExpress|{Lemzoparlimab} CD47|{Lemzoparlimab} Purity & Documentation|{Lemzoparlimab} In Vitro|{Lemzoparlimab} supplier|{Lemzoparlimab} Cancer} 01M TBS(pH7.PMID:23290930 4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Subtype:
IgG
Purification method :
Protein A affinity purified.
ELTSA :
Molecular weight :
132 KDa
Positive control :
Specifically expressed in cartilage. Localizes in the intermediates layer of articular cartilage but neither in the superficial nor in the deepest regions. Specifically and highly expressed in intervertebral disk tissue. Expression increases with aging in hip articular cartilage. Overexpressed in articular hyaline cartilage from patients with calcium pyrophosphate dihydrate crystal deposition disease (CPPD). Expression in intervertebral disk tissue from individuals with lumbar disk disease increases as disk degeneration progresses.