Product Name :
PF-06928215
Description:
PF-06928215 is a cGAS (cyclic GMP-AMP Synthase) inhibitor with an IC50 of 4.9 μΜ. PF-06928215 has a high binding affinity of 0.2 μM (Kd).
CAS:
2378173-15-8
Molecular Weight:
380.40
Formula:
C20H20N4O4
Chemical Name:
(1R,2S)-2-{7-oxo-5-phenyl-1H,7H-pyrazolo[1,5-a]pyrimidine-3-amido}cyclohexane-1-carboxylic acid
Smiles :
OC(=O)[C@@H]1CCCC[C@@H]1NC(=O)C1=CNN2C1=NC(=CC2=O)C1C=CC=CC=1
InChiKey:
WGQGCLHXUPGUSZ-HIFRSBDPSA-N
InChi :
InChI=1S/C20H20N4O4/c25-17-10-16(12-6-2-1-3-7-12)22-18-14(11-21-24(17)18)19(26)23-15-9-5-4-8-13(15)20(27)28/h1-3,6-7,10-11,13,15,21H,4-5,8-9H2,(H,23,26)(H,27,28)/t13-,15+/m1/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{15-Deoxy-Δ-12,14-prostaglandin J2} medchemexpress|{15-Deoxy-Δ-12,14-prostaglandin J2} Vitamin D Related/Nuclear Receptor|{15-Deoxy-Δ-12,14-prostaglandin J2} Technical Information|{15-Deoxy-Δ-12,14-prostaglandin J2} Data Sheet|{15-Deoxy-Δ-12,14-prostaglandin J2} custom synthesis|{15-Deoxy-Δ-12,14-prostaglandin J2} Epigenetic Reader Domain}
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
PF-06928215 is a cGAS (cyclic GMP-AMP Synthase) inhibitor with an IC50 of 4.9 μΜ. PF-06928215 has a high binding affinity of 0.2 μM (Kd).|Product information|CAS Number: 2378173-15-8|Molecular Weight: 380.40|Formula: C20H20N4O4|Chemical Name: (1R,2S)-2-{7-oxo-5-phenyl-1H,7H-pyrazolo[1,5-a]pyrimidine-3-amido}cyclohexane-1-carboxylic acid|Smiles: OC(=O)[C@@H]1CCCC[C@@H]1NC(=O)C1=CNN2C1=NC(=CC2=O)C1C=CC=CC=1|InChiKey: WGQGCLHXUPGUSZ-HIFRSBDPSA-N|InChi: InChI=1S/C20H20N4O4/c25-17-10-16(12-6-2-1-3-7-12)22-18-14(11-21-24(17)18)19(26)23-15-9-5-4-8-13(15)20(27)28/h1-3,6-7,10-11,13,15,21H,4-5,8-9H2,(H,23,26)(H,27,28)/t13-,15+/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 33.{{Tapinarof} MedChemExpress|{Tapinarof} Immunology/Inflammation|{Tapinarof} Protocol|{Tapinarof} References|{Tapinarof} custom synthesis|{Tapinarof} Epigenetic Reader Domain} 33 mg/mL (87.PMID:24238102 62 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|PF-06928215 displays no activity in cellular cGAS assays measuring dsDNA-induced IFN-beta expression.|Products are for research use only. Not for human use.|