CFHR5 Mouse Monoclonal Antibody

Function :
Involved in complement regulation. The dimerized forms have avidity for tissue-bound complement fragments and efficiently compete with the physiological complement inhibitor CFH.This gene is a member of a small complement factor H (CFH) gene cluster on chromosome 1. Each member of this gene family contains multiple short consensus repeats (SCRs) typical of regulators of complement activation.{{Etrasimod} medchemexpress|{Etrasimod} LPL Receptor|{Etrasimod} Biological Activity|{Etrasimod} In Vivo|{Etrasimod} manufacturer|{Etrasimod} Autophagy} The protein encoded by this gene has nine SCRs with the first two repeats having heparin binding properties, a region within repeats 5-7 having heparin binding and C reactive protein binding properties, and the C-terminal repeats being similar to a complement component 3 b (C3b) binding domain.{{Quavonlimab} MedChemExpress|{Quavonlimab} Immunology/Inflammation|{Quavonlimab} Purity & Documentation|{Quavonlimab} Formula|{Quavonlimab} custom synthesis|{Quavonlimab} Cancer} This protein co-localizes with C3, binds C3b in a dose-dependent manner, and is recruited to tissues damaged by C-reactive protein. Allelic variations in this gene have been associated, but not causally linked, with two different forms of kidney disease: membranoproliferative glomerulonephritis type II (MPGNII) and hemolytic uraemic syndrome (HUS).PMID:28739548