Product Name :
ADAM10 Recombinant Rabbit Monoclonal Antibody [JM32-11]
Predicted band size :
84 kDa
Observed band size :
75/100 kDa
Synonyms:
A disintegrin and metalloprotease domain 10 antibody A disintegrin and metalloproteinase domain 10 antibody AD 10 antibody AD10 antibody AD18 antibody ADA10_HUMAN antibody ADAM 10 antibody ADAM metallopeptidase domain 10 antibody ADAM10 antibody CD 156c antibody 展开
Function :
ADAM (a disintegrin and metalloprotease) proteins are a family of over 30 membrane-anchored, glycosylated, Zn2+ dependent proteases that are involved in cell-cell, cell-matrix interface related processes including fertilization, muscle fusion, secretion of TNFα (tumor necrosis factor α), and modulation of the neurogenic function of Notch and Delta. ADAM proteins possess a signal-domain, a pro-domain, a metalloprotease domain, a disintegrin domain (integrin ligand) a cysteine-rich region, an epidermal growth factor-like domain, a transmembrane domain and a cytoplasmic tail. ADAMs are expressed in brain, testis, epididymis, ovary, breast, placenta, liver, heart, lung, bone and muscle, and catalyze proteolysis, adhesion, fusion and intracellular signaling. ADAM10 is a TNF-processing enzyme that cleaves pro-TNF, a membrane-bound precusor protein, at Ala 76-Val 77, which causes membrane shedding of soluble TNF.
Antibody Type:
Recombinant Rabbit monoclonal Antibody
Immunogen :
Synthetic peptide within Human ADAM10 aa 715-748 / 748.
Species reactivity:
Human, Mouse, Rat
Verify application:
WB, IP, IHC-P
Coupling :
unconjugated
Clone number:
JM32-11
RRID:
AB_3070416
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃.{{Phorbol 12-myristate 13-acetate} medchemexpress|{Phorbol 12-myristate 13-acetate} Epigenetics|{Phorbol 12-myristate 13-acetate} Protocol|{Phorbol 12-myristate 13-acetate} Data Sheet|{Phorbol 12-myristate 13-acetate} manufacturer|{Phorbol 12-myristate 13-acetate} Cancer} Avoid repeated freeze / thaw cycles.{{Sacubitril} web|{Sacubitril} Metabolic Enzyme/Protease|{Sacubitril} Technical Information|{Sacubitril} Description|{Sacubitril} manufacturer|{Sacubitril} Autophagy}
Storage buffer solution:
1*TBS (pH7.PMID:25558565 4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Subtype:
IgG
Purification method :
Protein A affinity purified.
ELTSA :
Molecular weight :
Predicted band size: 84 kDa
Positive control :
Jurkat cell lysate, HeLa cell lysate, human lung tissue lysate, RAW264.7 cell lysate, mouse placenta tissue lysate, mouse brain tissue lysate, rat brain tissue lysate, rat spleen tissue lysate, human thyroid carcinoma tissue, human stomach tissue.