Product Name :
CDK5RAP3 Rabbit Polyclonal Antibody
Predicted band size :
Observed band size :
Synonyms:
C53 antibody CDK5 activator binding protein C53 antibody CDK5 activator-binding protein C53 antibody CDK5 regulatory subunit associated protein 3 antibody CDK5 regulatory subunit-associated protein 3 antibody Cdk5rap3 antibody CK5P3_HUMAN antibody HSF 27 antibody HSF27 antibody IC53 antibody 展开
Function :
Probable tumor suppressor initially identified as a CDK5R1 interactor controlling cell proliferation . Negatively regulates NF-kappa-B-mediated gene transcription through the control of RELA phosphorylation . Also regulates mitotic G2/M transition checkpoint and mitotic G2 DNA damage checkpoint. Through its interaction with CDKN2A/ARF and MDM2 may induce MDM2-dependent p53/TP53 ubiquitination, stabilization and activation in the nucleus, thereby promoting G1 cell cycle arrest and inhibition of cell proliferation . May play a role in the unfolded protein response, mediating the ufmylation of multiple proteins in response to endoplasmic reticulum stress . May also play a role in the rupture of the nuclear envelope during apoptosis . May regulate MAPK14 activity by regulating its dephosphorylation by PPM1D/WIP1
Antibody Type:
Rabbit Polyclonal Antibody
Immunogen :
Recombinant protein within Human CDK5RAP3 aa 296-506 / 506.
Species reactivity:
Human
Verify application:
WB, IF-Cell, FC
Coupling :
unconjugated
Clone number:
RRID:
AB_3069456
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at +4℃ after thawing.{{Pralatrexate} site|{Pralatrexate} Apoptosis|{Pralatrexate} Biological Activity|{Pralatrexate} In stock|{Pralatrexate} custom synthesis|{Pralatrexate} Epigenetic Reader Domain} Aliquot store at -20℃.{{Pramlintide} MedChemExpress|{Pramlintide} GPCR/G Protein|{Pramlintide} Purity & Documentation|{Pramlintide} References|{Pramlintide} custom synthesis|{Pramlintide} Epigenetic Reader Domain} Avoid repeated freeze / thaw cycles.PMID:23443926
Storage buffer solution:
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Subtype:
IgG
Purification method :
Immunogen affinity purified.
ELTSA :
Molecular weight :
Predicted band size 57 kDa
Positive control :
MCF-7 cell lysates, LOVO, PC-3M, SHSY5Y.