Product Name :
SR3335
Description:
SR3335, also known as ML 176, is a RORα selective inverse agonist. SR3335 directly binds to RORα, but not other RORs, and functions as a selective partial inverse agonist of RORα in cell-based assays. Furthermore, SR3335 suppresses the expression of endogenous RORα target genes in HepG2 involved in hepatic gluconeogenesis including glucose-6-phosphatase and phosphoenolpyruvate carboxykinase. SR3335 can be utilized as a chemical tool to probe the function of this receptor both in vitro and in vivo. SR3335 may hold utility for suppression of elevated hepatic glucose production in type 2 diabetics.
CAS:
293753-05-6
Molecular Weight:
405.34
Formula:
C13H9F6NO3S2
Chemical Name:
N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]thiophene-2-sulfonamide
Smiles :
OC(C1C=CC(=CC=1)NS(=O)(=O)C1=CC=CS1)(C(F)(F)F)C(F)(F)F
InChiKey:
LZWUNZRMANFRAO-UHFFFAOYSA-N
InChi :
InChI=1S/C13H9F6NO3S2/c14-12(15,16)11(21,13(17,18)19)8-3-5-9(6-4-8)20-25(22,23)10-2-1-7-24-10/h1-7,20-21H
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Treprostinil} site|{Treprostinil} GPCR/G Protein|{Treprostinil} Purity & Documentation|{Treprostinil} In Vitro|{Treprostinil} supplier|{Treprostinil} Epigenetic Reader Domain}
Shelf Life:
≥360 days if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
SR3335, also known as ML 176, is a RORα selective inverse agonist. SR3335 directly binds to RORα, but not other RORs, and functions as a selective partial inverse agonist of RORα in cell-based assays. Furthermore, SR3335 suppresses the expression of endogenous RORα target genes in HepG2 involved in hepatic gluconeogenesis including glucose-6-phosphatase and phosphoenolpyruvate carboxykinase.{{Rocatinlimab} web|{Rocatinlimab} Protocol|{Rocatinlimab} In Vitro|{Rocatinlimab} supplier|{Rocatinlimab} Autophagy} SR3335 can be utilized as a chemical tool to probe the function of this receptor both in vitro and in vivo.PMID:23551549 SR3335 may hold utility for suppression of elevated hepatic glucose production in type 2 diabetics.|Product information|CAS Number: 293753-05-6|Molecular Weight: 405.34|Formula: C13H9F6NO3S2|Chemical Name: N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]thiophene-2-sulfonamide|Smiles: OC(C1C=CC(=CC=1)NS(=O)(=O)C1=CC=CS1)(C(F)(F)F)C(F)(F)F|InChiKey: LZWUNZRMANFRAO-UHFFFAOYSA-N|InChi: InChI=1S/C13H9F6NO3S2/c14-12(15,16)11(21,13(17,18)19)8-3-5-9(6-4-8)20-25(22,23)10-2-1-7-24-10/h1-7,20-21H|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥360 days if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|