Product Name :
HWL-088
Description:
HWL-088 is a highly potent and orally active free fatty acid receptor 1 (FFA1/GPR40) agonist (EC50 of 18.9 nM) with moderate PPARδ activity (EC50 of 570.9 nM) . HWL-088 improves glucose and lipid metabolism, and has anti-diabetic effects.
CAS:
2378617-96-8
Molecular Weight:
366.38
Formula:
C22H19FO4
Chemical Name:
2-[2-fluoro-4-({2′-methyl-[1,1′-biphenyl]-3-yl}methoxy)phenoxy]acetic acid
Smiles :
CC1=CC=CC=C1C1=CC(COC2=CC(F)=C(C=C2)OCC(O)=O)=CC=C1
InChiKey:
NJYJBYPNDWNZAH-UHFFFAOYSA-N
InChi :
InChI=1S/C22H19FO4/c1-15-5-2-3-8-19(15)17-7-4-6-16(11-17)13-26-18-9-10-21(20(23)12-18)27-14-22(24)25/h2-12H,13-14H2,1H3,(H,24,25)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
HWL-088 is a highly potent and orally active free fatty acid receptor 1 (FFA1/GPR40) agonist (EC50 of 18.{{Guanidine} web|{Guanidine} Metabolic Enzyme/Protease|{Guanidine} Technical Information|{Guanidine} In Vitro|{Guanidine} custom synthesis|{Guanidine} Epigenetic Reader Domain} 9 nM) with moderate PPARδ activity (EC50 of 570.{{Daptomycin} site|{Daptomycin} Bacterial|{Daptomycin} Technical Information|{Daptomycin} In stock|{Daptomycin} supplier|{Daptomycin} Autophagy} 9 nM) .PMID:23880095 HWL-088 improves glucose and lipid metabolism, and has anti-diabetic effects.|Product information|CAS Number: 2378617-96-8|Molecular Weight: 366.38|Formula: C22H19FO4|Chemical Name: 2-[2-fluoro-4-({2′-methyl-[1,1′-biphenyl]-3-yl}methoxy)phenoxy]acetic acid|Smiles: CC1=CC=CC=C1C1=CC(COC2=CC(F)=C(C=C2)OCC(O)=O)=CC=C1|InChiKey: NJYJBYPNDWNZAH-UHFFFAOYSA-N|InChi: InChI=1S/C22H19FO4/c1-15-5-2-3-8-19(15)17-7-4-6-16(11-17)13-26-18-9-10-21(20(23)12-18)27-14-22(24)25/h2-12H,13-14H2,1H3,(H,24,25)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 250 mg/mL (682.35 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|HWL-088 (0.3 μM and 3μM) significantly increases insulin secretion fromMIN6 cells at 25 mM but not at 2 mM glucose. HWL-088 reveales a dose-dependent insulinotropic effect in the presence of 25-mM glucose.|In Vivo:|HWL-088 (40 mg/kg; oral gavage; daily; for 30 days; ob/ob mice) treatment improves β-cell function by up-regulation of pancreas duodenum homeobox-1, reduces fat accumulation in adipose tissue and alleviated fatty liver in ob/ob mice. The effect of HWL-088 involves a reduction in hepatic lipogenesis and oxidative stress, increased lipoprotein lipolysis, glucose uptake, mitochondrial function and fatty acid β-oxidation.|Products are for research use only. Not for human use.|