Product Name :
CD89 Recombinant Rabbit Monoclonal Antibody [JE38-41]
Predicted band size :
32 kDa
Observed band size :
75 kDa
Synonyms:
CD89 antibody Fc alpha receptor antibody Fc fragment of IgA, receptor for antibody FCAR antibody FCAR_HUMAN antibody IgA Fc receptor antibody Immunoglobulin alpha Fc receptor antibody
Function :
Fc fragment of IgA receptor (FCAR) is a human gene[3] that codes for the transmembrane receptor FcαRI, also known as CD89 (Cluster of Differentiation 89). FcαRI binds the heavy-chain constant region of Immunoglobulin A (IgA) antibodies. FcαRI is present on the cell surface of myeloid lineage cells, including neutrophils, monocytes, macrophages, and eosinophils, though it is notably absent from intestinal macrophages and does not appear on mast cells. FcαRI plays a role in both pro- and anti-inflammatory responses depending on the state of IgA bound. Inside-out signaling primes FcαRI in order for it to bind its ligand, while outside-in signaling caused by ligand binding depends on FcαRI association with the Fc receptor gamma chain (FcR γ-chain). Though FcαRI is part of the Fc receptor immunoglobulin superfamily, the protein’s primary structure is similar to receptors in the leukocyte receptor cluster (LRC), and the FCAR gene appears amidst LRC genes on chromosome 19.{{Avexitide} site|{Avexitide} GCGR|{Avexitide} Protocol|{Avexitide} References|{Avexitide} manufacturer|{Avexitide} Autophagy} This contrasts with the location of other members of the Fc receptor immunoglobulin superfamily, which are encoded on chromosome 1.{{LB-100} medchemexpress|{LB-100} Phosphatase|{LB-100} Protocol|{LB-100} Purity|{LB-100} custom synthesis|{LB-100} Epigenetics} Additionally, though there are equivalents to FCAR in several species, there is no such homolog in mice.PMID:23546012
Antibody Type:
Recombinant Rabbit monoclonal Antibody
Immunogen :
Recombinant protein within
Species reactivity:
Human
Verify application:
WB, IF-Cell
Coupling :
unconjugated
Clone number:
JE38-41
RRID:
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
Storage buffer solution:
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Subtype:
IgG
Purification method :
Peptide affinity purified.
ELTSA :
Molecular weight :
Predicted band size: 32 kDa
Positive control :
HL-60 cell lysate, Raji cell lysate, A549 cell lysate, U-87 MG cell lysate, Jurkat cell lysate, Human lung tissue lysate, HL-60.