Product Name :
CD84 Recombinant Rabbit Monoclonal Antibody [JE59-27]
Predicted band size :
Observed band size :
Synonyms:
CD_antigen=CD84 antibody CD84 antibody CD84 antigen antibody CD84 molecule antibody CDw84 antibody Cell surface antigen MAX.3 antibody hCD84 antibody Hly9 beta antibody Hly9-beta antibody Leucocyte differentiation antigen CD84 antibody 展开
Function :
Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Can mediate natural killer (NK) cell cytotoxicity dependent on SH2D1A and SH2D1B. Increases proliferative responses of activated T-cells and SH2D1A/SAP does not seem be required for this process. Homophilic interactions enhance interferon gamma/IFNG secretion in lymphocytes and induce platelet stimulation via a SH2D1A-dependent pathway.{{Phosphorylase kinase} medchemexpress|{Phosphorylase kinase} Biological Activity|{Phosphorylase kinase} Formula|{Phosphorylase kinase} supplier|{Phosphorylase kinase} Autophagy} May serve as a marker for hematopoietic progenitor cells.{{Neflamapimod} medchemexpress|{Neflamapimod} MAPK/ERK Pathway|{Neflamapimod} Purity & Documentation|{Neflamapimod} In Vitro|{Neflamapimod} supplier|{Neflamapimod} Epigenetics} Required for a prolonged T-cell:B-cell contact, optimal T follicular helper function, and germinal center formation. In germinal centers involved in maintaining B-cell tolerance and in preventing autoimmunity. In mast cells negatively regulates high affinity immunoglobulin epsilon receptor signaling; independent of SH2D1A and SH2D1B but implicating FES and PTPN6/SHP-1. In macrophages enhances LPS-induced MAPK phosphorylation and NF-kappaB activation and modulates LPS-induced cytokine secretion; involving ITSM 2. Positively regulates macroautophagy in primary dendritic cells via stabilization of IRF8; inhibits TRIM21-mediated proteasomal degradation of IRF8.
Antibody Type:
Recombinant Rabbit monoclonal Antibody
Immunogen :
Synthetic peptide within human CD84 aa aa 296-345/345.
Species reactivity:
Human
Verify application:
WB, IHC-P
Coupling :
unconjugated
Clone number:
JE59-27
RRID:
AB_3071977
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at +4℃ after thawing.PMID:24957087 Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
Storage buffer solution:
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Subtype:
IgG
Purification method :
Protein A affinity purified.
ELTSA :
Molecular weight :
Predicted band size: 70 kDa
Positive control :
THP-1 and Daudi cell lysates, human spleen tissue.