Product Name :
CD83 Recombinant Rabbit Monoclonal Antibody [JE33-61]
Predicted band size :
23 kDa
Observed band size :
35-45 kDa
Synonyms:
B cell activation 45kDa cell surface glycoprotein Ig superfamily antibody B cell activation protein antibody B-cell activation protein antibody BL11 antibody BL11 PEN antibody CD83 antibody CD83 antigen (activated B lymphocytes, immunoglobulin superfamily) antibody CD83 antigen antibody CD83 molecule antibody CD83_HUMAN antibody 展开
Function :
CD83 (Cluster of Differentiation 83) is a human protein encoded by the CD83 gene. The membrane-bound form of CD83 consists of an extracellular V-type immunoglobulin-like domain, a transmembrane domain and a cytoplasmic signaling tail. A free soluble form consists of the immunoglobulin-like domain alone. Membrane-bound CD83 is expected to form trimers.{{ATP} medchemexpress|{ATP} Endogenous Metabolite|{ATP} Biological Activity|{ATP} Data Sheet|{ATP} supplier|{ATP} Epigenetics} Soluble CD83 is able to assemble into dodecameric complexes.{{Risdiplam} web|{Risdiplam} Cell Cycle/DNA Damage|{Risdiplam} Purity & Documentation|{Risdiplam} In stock|{Risdiplam} manufacturer|{Risdiplam} Epigenetic Reader Domain} The CD83 gene is located on human chromosome 6p23 and mouse chromosome 13. In humans, a promoter 261 bp upstream consists of five NF-κB and three interferon regulatory factor binding sites, reflecting the involvement of CD83 in inflammation, as well as binding sites for the aryl hydrocarbon receptor.PMID:23558135 The latter also occur in an enhancer sequence located 185 bp downstream, inside the second intron, and may suggest negative regulation of transcription by microbial metabolites produced in the gut.
Antibody Type:
Recombinant Rabbit monoclonal Antibody
Immunogen :
Synthetic peptide within Human CD83 aa 51-100 / 205.
Species reactivity:
Human
Verify application:
WB
Coupling :
unconjugated
Clone number:
JE33-61
RRID:
AB_3072672
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
Storage buffer solution:
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Subtype:
IgG
Purification method :
Protein A affinity purified.
ELTSA :
Molecular weight :
Predicted band size: 23 kDa
Positive control :
Raji cell lysate, Jurkat cell lysate, U-937 cell lysate.