CD79a Mouse Monoclonal Antibody [C1-E8]

Function :
Cluster of differentiation CD79A also known as B-cell antigen receptor complex-associated protein alpha chain and MB-1 membrane glycoprotein, is a protein that in humans is encoded by the CD79A gene.{{Verapamil} web|{Verapamil} Neuronal Signaling|{Verapamil} Biological Activity|{Verapamil} References|{Verapamil} supplier|{Verapamil} Autophagy} The CD79a protein together with the related CD79b protein, forms a dimer associated with membrane-bound immunoglobulin in B-cells, thus forming the B-cell antigen receptor (BCR). This occurs in a similar manner to the association of CD3 with the T-cell receptor, and enables the cell to respond to the presence of antigens on its surface. It is associated with agammaglobulinemia-3. CD79a plays multiple and diverse roles in B cell development and function. The CD79a/b heterodimer associates non-covalently with the immunoglobulin heavy chain through its transmembrane region, thus forming the BCR along with the immunoglobulin light chain and the pre-BCR when associated with the surrogate light chain in developing B cells.{{6α-Methylprednisolone 21-hemisuccinate sodium salt} web|{6α-Methylprednisolone 21-hemisuccinate sodium salt} Glucocorticoid Receptor|{6α-Methylprednisolone 21-hemisuccinate sodium salt} Protocol|{6α-Methylprednisolone 21-hemisuccinate sodium salt} In Vitro|{6α-Methylprednisolone 21-hemisuccinate sodium salt} supplier|{6α-Methylprednisolone 21-hemisuccinate sodium salt} Autophagy} Association of the CD79a/b heterodimer with the immunoglobulin heavy chain is required for surface expression of the BCR and BCR induced calcium flux and protein tyrosine phosphorylation.PMID:24631563 Genetic deletion of the transmembrane exon of CD79A results in loss of CD79a protein and a complete block of B cell development at the pro to pre B cell transition. Similarly, humans with homozygous splice variants in CD79A predicted to result in loss of the transmembrane region and a truncated or absent protein display agammaglobulinemia and no peripheral B cells.